Active Compounds in Green Tea and Red Wine Halt Alzheimer’s Disease Progression

Alzheimer’s disease is characterized by an unnatural accumulation of amyloid plaque aggregates around nerve synapses that block the transmission of electrical and chemical transmitters that allow the brain to retain a high level of cognitive function and to store and retain memories. Millions of middle aged and older Americans suffer from some stage of Alzheimer’s disease, as the illness continues to escalate at an epidemic rate. It is projected that the prevalence will nearly quadruple in the next 50 years, by which time approximately 1 in 45 Americans will be afflicted with the disease.

Green Tea and Red Wine Extracts Impede Amyloid Formation to Prevent Alzheimer’s Development

The past decade has uncovered a small handful of natural, bioactive compounds that easily cross the blood-brain barrier where they have been found to alter the progression of Alzheimer’s disease. Researchers from the University of Leeds in the UK have determined that natural chemicals found in green tea and red wine may disrupt a key step of the Alzheimer's disease pathway. Publishing in the Journal of Biological Chemistry, scientists have identified the process which allows harmful clumps of protein to latch on to brain cells, causing them to die.

Scientists understand that amyloid proteins in the brain clump together to form toxic, sticky balls of varying shapes. These amyloid balls latch on to the surface of nerve cells in the brain by attaching to proteins on the cell surface called prions, ultimately causing nerve cells to malfunction and die. Study co-author Dr. Jo Rushworth commented "We wanted to investigate whether the precise shape of the amyloid balls is essential for them to attach to the prion receptors, like the way a baseball fits snugly into its glove.”

Supplement Daily with EGCG and Resveratrol to Slow Disease Progression

The team wanted to determine if it was possible to prevent the amyloid balls from binding to prions by manipulating their shape and stop the cells from dying. Scientists formed amyloid balls in a test tube and then added them to human and animal brain cells. Study authors concluded "When we added the extracts from red wine and green tea, which recent research has shown to re-shape amyloid proteins, the amyloid balls no longer harmed the nerve cells.”

Researchers determined that the bioactive compounds in green tea and red wine (EGCG and resveratrol) distorted the shape of the amyloid balls, preventing them from binding with prions and disrupting cellular function. Complimentary studies have also determined that curcumin, the active compound in the curry spice turmeric, crossed the delicate blood-brain barrier to halt the advancement of dementia. Health-minded individuals should consume green tea and red wine or take standardized supplements regularly to help prevent the initial development and progression of Alzheimer’s disease.

Resveratrol Protects against Blood Sugar Surges to Prevent Diabetes and Improve Cardiovascular Health

Allopathic practitioners and the pharmaceutical giants enjoy promoting natural compounds including resveratrol as worthless, akin to snake oil and frequently attempt to convince the public that they are wasting their money by using these supplements. Naturally, the big medical concerns make huge profits by selling a host of prescription drugs that account for more than 100,000 deaths every year, even when taken as prescribed. Not a single death has been recorded from using resveratrol, yet the health benefits are profoundly significant and repeatedly documented in peer reviewed scientific studies.

Scientists Detail how Resveratrol Prevents Damage from High Blood Glucose to Maintain Vascular Function

Researchers from China have published the results of a study in the journal, Genes and Nutrition, showing how resveratrol protects against common damage to the arteries that leads to atherosclerosis and cardiovascular dysfunction. While the scientists specifically detailed how the natural compound helps prevent complications in diabetics where fasting and post meal blood glucose can surge from three to five times normal, many health-conscious individuals can benefit from this information to protect them from arterial deterioration frequently associated with cardiovascular disease and increased heart attack risk.

Our arteries are lined with a delicate, single cell layer of tissue called the endothelium that is essential to maintain proper blood pressure and volume, and acts as a barrier to protect against metabolic byproducts floating in circulation. The endothelium is very sensitive to excess levels of glucose in the bloodstream and can become damaged and tear when sugar crystals remain in circulation for extended periods, such as occurs after a meal high in sugars and refined carbohydrates. When the endothelium is breached, micro cracks occur that accumulate foamy plaque leading to future coronary artery disease.

Supplement Daily with Resveratrol to Preserve Vascular Health and Halt AGE Formation

Scientists found that blood sugar surges caused the endothelium to become permeable, allowing oxidized LDL cholesterol, calcium and other circulating materials to become lodged inside the arterial wall. The study team determined that resveratrol stopped endothelial leaking and helped maintain proper vascular structure even under stressful conditions experienced with high blood sugar levels. Further, the researchers detailed the precise mechanism exerted by the compound to maintain the structural integrity of the arterial wall.

The team concluded that resveratrol helped prevent the most common type of arterial damage caused by poor diet and advanced aging. Advanced glycation end products (AGE’s) are formed when blood sugars and protein become bound to form useless structures that can adhere to and damage our arteries. Resveratrol (nutritionists recommend 400 mg of a standardized formulation per day) was shown to halt this damage and provides a critical nutritional intervention to prevent complications and maintain cardiovascular health in both diabetics and healthy individuals.

Resveratrol May Help to Prevent and Even Treat Alzheimer’s Disease

Incidence of Alzheimer’s disease cases continue to explode at an unprecedented rate as processed food diets, overweight and obesity become the norm for middle and senior aged adults in the US and most western societies. By the year 2050, it’s projected that 13.2 million adults will suffer from this degenerative disease that ranks as the sixth leading cause of death, with many suffering early signs of the condition at earlier ages. Any natural compound that can be shown to prevent or even treat Alzheimer’s disease would be a potent therapeutic tool.

Resveratrol Confirm the Benefits of Resveratrol to Fight Alzheimer’s Disease

Researchers from Georgetown University Medical Center's Memory Disorders Program have embarked on a mission to demonstrate that resveratrol can affect memory deterioration and daily functioning in people with mild to moderate dementia due to Alzheimer's disease. Resveratrol is a natural compound found in red grapes, red grape juice, red wine, chocolate, tomatoes and peanuts. In prior studies, the polyphenol has been shown to help prevent diabetes, act as a natural cancer fighter, ward off cardiovascular disease, and prevent memory loss.

As the risk of many chronic conditions increase with aging, resveratrol exhibits unique characteristics as it has been shown to impede telomere shortening and extend natural cell life and activity. Resveratrol has also been shown to improve glucose metabolism and insulin sensitivity, two mechanisms known to speed the aging process.

Supplement with Resveratrol Daily to Lower the Risk of Developing Alzheimer’s Dementia

Researchers will examine the direct impact of pure resveratrol supplementation on neural aging and amyloid protein clearance. Recent research has suggested that Alzheimer’s disease may result from insulin resistance specifically in the brain, and as resveratrol is known to cross the blood-brain barrier, the compound may prevent faulty insulin signaling that promotes the degenerative condition.

This is the largest and most extensive study of its kind developed to validate the brain health benefits of resveratrol. Researchers will recruit participants from 26 U.S. academic institutions that are affiliated with the Alzheimer's Disease Cooperative Study around the country. This study is unique because it is designed to demonstrate the impact of a natural compound and not a patentable pharmaceutical drug.

Resveratrol is supplied in small amounts from dietary sources including red grapes, red wine, chocolate and tomatoes. Nutrition experts recommend supplementing with a pure extract (20 to 500 mg per day) for optimal protection against Alzheimer’s disease and a myriad of chronic conditions.

Resveratrol Provides Anti-Aging Benefits and Helps Prevent Heart Disease

Resveratrol has been a popular buzz word around the alternative health community for more than a decade, touted for its anti-aging properties and potent antioxidant and anti-inflammatory actions at the cellular level. Found in high concentrations most commonly in the skin of red grapes and in many red wines, resveratrol is thought to mimic the positive health benefits associated with calorie restriction by up-regulating longevity genes known as SIRT’s.

Scientists from the Harvard Medical School have published the result of their work in the journal, Cell Biology that demonstrates how resveratrol provides metabolic benefits as a result of directly influencing the expression of genes that affect longevity. This research confirms conclusively for the first time that the metabolic benefits of the red wine ingredient disappear in mice that lack the famed longevity gene SIRT1.

Resveratrol Directly Influences Genetic Expression to Increase Lifespan

Resveratrol, commonly referred to as a ‘dirty molecule’, has gained notoriety for its unique ability to influence or alter the genetic expression of the SIRT family of longevity genes. Researchers have discovered that the naturally occurring ingredient has other effects; it influences dozens of other proteins critical to essential metabolic functions, and some evidence had pointed to the importance of another well-known gene (called AMPK) for resveratrol's cellular benefits.

Researchers using a mouse model determined that resveratrol did not affect a group of mice that were genetically bred to ‘knock-out’ the SIRT gene (mice are commonly used for this type of study as they exhibit similar metabolic traits with humans). This confirmed that the grape-derived compound directly alters longevity expression in a dose dependent manner. Higher concentrations of resveratrol were found to increase the degree of genetic influence exhibited by resveratrol supplementation.

Resveratrol Lowers Systemic Inflammation to Reduce Heart Disease Risk

Further evidence documenting the importance of resveratrol to human health is provided by researchers publishing in the American Journal of Cardiology. Scientists found that cardiac patients supplemented for a period of one year with the red nutrient lowered multiple markers of inflammation (including CRP, C-reactive protein) by 26 percent, as well as reduced clotting factors associated with stroke. The researchers for this study used low doses of resveratrol (8 mg for the first six months and 16 mg for the next six months) to achieve these results.

A vocal group of naysayers constantly degrade the ever-growing evidence to support the importance of resveratrol to human wellbeing. There is little left to dispute, as researchers are regularly demonstrating that small amounts of resveratrol taken from diet or supplementation can benefit overall wellness and cardiovascular diseases by lowering levels of inflammation, providing antioxidant support and directly altering genetic expression to extend our healthy lifespan.

Red Grape Compounds Aid Weight Management to Help Prevent Obesity

Obesity and overweight are threatening the health and lives of nearly seventy percent of the US population, and indicators are this epidemic is continuing to affect even more men, women and children as it places a significant burden on an already failing health care system. Most health-minded individuals understand the importance of eliminating refined and processed foods while maintaining constant blood glucose and insulin levels to achieve individual weight management goals.

Researchers from Purdue University have published the result of a study in the Journal of Biological Chemistry that demonstrates the potent nature of natural compounds found in red wine and many fruits to block cellular processes that allow fat cells to develop. Scientists found that the compound piceatannol, found naturally in the skin of grapes and other fruits blocks an immature fat cell's ability to develop and grow, opening a door to a potential method to control obesity.

Piceatannol Inhibits the Formation of Mature Fat Cells to Achieve Weight Management Goals

The lead study author, Dr. Kee-Hong Kim found that piceatannol, an analog of resveratrol found in grapes and other fruit, is converted to piceatannol in humans following its consumption. The team tested piceatannol in cultured immature fat cells called preadipocytes to determine if the compound inhibited the maturity process that results in fully developed fat cells, capable of storing body fat and contributing to obesity.

Dr. Kim commented “We consider that adipogenesis is an important molecular target to delay or prevent fat cell accumulation and, hopefully, body fat mass gain.” The team found that piceatannol bound to the insulin receptor on the immature fat cells, effectively blocking insulin’s ability to control normal cellular cycling resulting in mature adipocytes. The grape-derived compound stimulated the activation of special genes necessary for the fat cell maturation process.

Eat a Wide Variety of Natural Fruits and Vegetables to Help Weight Loss Issues

The study authors concluded “Piceatannol actually alters the timing of gene expressions, gene functions and insulin action during adipogenesis, the process in which early stage fat cells become mature fat cells… in the presence of piceatannol, you can see delay or complete inhibition of adipogenesis.” Similar in structure to resveratrol, scientists believe piceatannol may also exert some of the same properties to help combat cancer, heart disease and neurodegenerative conditions.

Piceatannol is yet another natural compound that has demonstrated the ability to influence genetic expression to inhibit the formation of adipocytes or alter metabolism to help achieve weight management goals alongside resveratrol, green tea catechins (EGCG) and irvingia gabonensis. When used to compliment a natural food diet void of wheat and refined carbohydrates, piceatannol may be an important component to achieve natural weight management goals.

Resveratrol and Nuts Combine to Improve Brain Health and Boost Cognitive Function

Nuts, especially walnuts, almonds and hazelnuts, combined with the potent polyphenol resveratrol team together to improve mood and protect the aging brain to help maintain memory and cognition. Researchers reporting in the New England Journal of Medicine have found that nuts consumed over a period of years not only help with weight management issues, but also can reduce systemic inflammation to improve spirits and prevent cognitive decline.

Resveratrol has long been associated with brain health. The Journal of Pineal Research reports that resveratrol demonstrates anti-aging properties in the brain necessary for energy production and optimal brain function. Combining these two natural agents together as part of your healthy diet can improve mood, help retain memories and preserve youthful thought patterns.

Nuts Improve Mood, Slash Brain Inflammation and Prevent Cognitive Decline

Researchers determined to validate the health-promoting capacity of nuts provided test participants with a diet of walnuts, almonds and hazelnuts for a period of 12 weeks. The volunteers for this study were sex and age-matched individuals given a control diet, and compared to a group not receiving the nut mixture. All participants exhibited symptoms of metabolic syndrome, increasing risk for developing diabetes, heart disease, mood disorders and loss of cognition.

Individuals receiving the nuts had increased levels of serotonin which will help a person feel better and potentially more satisfied and less likely to suffer from depression and poor mood. Additionally, the nut control group demonstrated reduced inflammatory markers from the high polyphenol content of the nuts. This is an important finding, as individuals exhibiting the signs of metabolic syndrome experience the effects of systemic inflammation leading to accelerated brain aging and cognitive decline.

Resveratrol Positively Influences Gene Expression to Restore Mitochondria Function

Mitochondria are the tiny metabolic engines that are responsible for powering each of our trillion or so cells throughout the body. Over time, mitochondria begin to experience loss of function and cellular decline and aging of the cell begin. Mitochondrial regulation is controlled in large part by the ‘longevity’ gene known as Sirt1. Calorie restriction and potent natural nutrients such as resveratrol are known to alter expression of the Sirt1 gene. Researchers have demonstrated that resveratrol is able to restore neural mitochondria function by reviving Sirt1 gene expression, and provides “a potent anti-aging effect within the brain.”

The human brain is a highly metabolic organ, demanding 20% of the total oxygen supply for the body. As such, it is also susceptible to the effects of oxidative stress and free radical damage that cause brain inflammation and advanced signs of aging. Natural nutrients such as resveratrol (25 – 50 mg per day) that cross the blood-brain barrier and foundation monounsaturated fats supplied by most nuts (1 to 2 ounces each day) and seeds protect the brain from damage and dramatically lower the risk of memory loss and cognitive decline.

Resveratrol and Pterostilbene Duo Combine to Improve Cognition and Mental Function

The potent phenolic compound resveratrol and its close cousin, pterostilbene have long been touted for their anti-cancer, anti-inflammatory and blood sugar-lowering health benefits. Information published in the prestigious journal publications, Neurobiology of Aging and The Journal of Nutritional Biochemistry both cite resveratrol and pterostilbene as powerful brain-boosting agents, enhancing cognitive and mental function while lowering the risk from many forms of dementia.

Pterostilbene, chemically similar to resveratrol, is a bioactive protective compound found commonly in many fresh fruits and vegetables. Numerous research studies show the two compounds acts to reduce inflammation throughout the body, a process behind seven of the ten most common disease processes that lead to death. Including this potent duo as part of your healthy diet, or from supplementation may help aid memory retention.

Resveratrol and Pterostilbene Stimulate Insulin Growth Factor to Impede Cognitive Decline

Resveratrol is a bioactive compound extracted most commonly from the skin of red grapes and found at differing concentrations in red wine. Researchers in Japan working with mice examined the effect of consuming red wine with a resveratrol concentration of 20 mg per liter, compared with a lower concentration of 3.1 mg per liter. A typical glass of red wine averages 4.7 mg per liter of resveratrol concentration.

The scientists found that the higher resveratrol concentration resulted in improved cognitive function using a variety of spatial and memory intensive tests. The benefits were linked to an increase in the production of a peptide called insulin-like growth-factor-I (IGF-I) that promotes the growth of blood vessels and neurons in the hippocampus region of the brain. Researchers commented “It is thus possible that drinking red wine with regular concentrations of resveratrol for long periods lowers the risk of age-associated cognitive decline.” Experts recommend an intake of 25 to 50 mg of resveratrol each day for optimal health effects.

Pterostilbene Lowers the Effect of Cellular Damage from Stress and Inflammation

In a separate research study conducted at Case Western Reserve University and Tufts University, two groups of mice were fed either identical doses of resveratrol or pterostilbene, about the equivalent of drinking two glasses of wine. While both compounds were found to boost levels of cognition, those receiving the pterostilbene demonstrated modulated markers of cellular stress and inflammation. This effect was not seen in the resveratrol supplemented mice.

The researchers concluded that because of the slight structural difference between the two compounds, “This change may lead to a better bioavailability of pterostilbene and consequently a more neuroprotective effect in the brain.” Pterostilbene is available naturally through a diet including blueberries, grapes, cranberries and olive oil or can be supplemented (50 mg per day) to meet nutritional goals. Both compounds provide a healthy synergistic effect that can help preserve memories and mental function as we age.

Resveratrol Reduces Breast Cancer Risk by Blocking the Effect of Estrogen

Researchers from the Faculty of Pharmacy at the University of Calabria in Italy publishing in The FASEB Journal report that resveratrol blocks the effect of estrogen and can help to prevent the malignant growth of breast cancer in women. The grape/red wine derivative has been the subject of numerous scientific studies in recent years and has shown promise in lowering risks from cardiovascular disease, cancer and dementia.

Scientists also believe the protective nutrient may extend healthy lifespan by directly influencing mortality genes known as SIRT. Italian researchers noted "Resveratrol is a potential pharmacological tool to be exploited when breast cancer become resistant to the hormonal therapy." Health-minded adults will want to include resveratrol from natural food sources or supplementation to reap the numerous health benefits.

Resveratrol Supplementation Suppresses the Growth of Malignant Breast Cancer Cells

To design their study, researchers used several breast cancer cell lines expressing the estrogen receptor to test the effects of resveratrol. They exposed the different cells to a solution containing resveratrol and compared the results to cells left untreated. They found an important reduction in cell growth in cells treated with resveratrol, while no changes were seen in untreated cells. Further experiments determined that this effect was caused by a critical reduction in estrogen receptors caused by the administration of resveratrol.

This finding is the first of its kind as it relates specifically to the effect of resveratrol on a particular cancer cell line. The team was able to conclude that resveratrol is able to counteract the malignant progression of breast cancer cells by inhibiting the growth and spread of hormone resistant cancerous cells. This has important implications for the treatment of women with breast cancer whose tumors eventually develop resistance to hormonal therapy.

Resveratrol Specifically Targets Cancerous Cells to Fight Breast Cancer

Lead researcher Dr. Sebastiano Ando noted "Resveratrol is a potential pharmacological tool to be exploited when breast cancer become resistant to the hormonal therapy." A peer review board examining the study data concluded “scientists haven't finished distilling the secrets of good health that have been hidden in natural products such as red wine.” It is important to note that in this body of research, resveratrol only demonstrated an effect on malignant cancer cells and exerted no effect on non-cancerous cells.

While the authors cautioned that people should not go out and start using red wine or resveratrol supplements as a treatment for breast cancer, the finding strongly indicates that the plant-protective compound should be considered as a component in an overall plan designed to prevent the devastating disease. Nutrition experts recommend a supplemental intake (from a purified, organically derived source) of between 50 and 250 mg per day for optimal health benefits.

Resveratrol and Vitamin D Team Together to Increase Metabolism and Prevent Obesity

Resveratrol has been on the nutritional radar of researchers because of its proven ability to mimic some of the life-extending characteristics provided by calorie restriction as seen in animals and humans alike. Scientists publishing in the journal Molecular Nutrition and Food Research draw a solid link between resveratrol, vitamin D and other phytonutrients as agents that may lend a helping hand in the life-threatening battle against overweight and obesity.

Researchers document the newly discovered effect of the nature-derived nutrient on lipid metabolism, and demonstrate that supplementation along with the sunshine vitamin and quercetin synergistically decreases the formation of new fat cells in the body. This finding is significant because it may provide a critical metabolic aid to children and adults that suffer the health-damaging effects of obesity every day. Further evidence exists to hail the trio in the genesis of osteoblasts in bone marrow that may offer a new therapy for osteoporosis that affects the mobility of millions of aging adults.

Resveratrol and Vitamin D Combine to Regulate Genes that Control Body Weight

Scientists studying metabolism in aging adults have found that stem cells differentiate in favor of adipocytes (fat cells) and to the exclusion of osteoblasts (cells necessary for the formation of new bone). This means that as we age, our body has evolved to store fat as an aid to our survival. As metabolism slows, we continue to eat the same number of calories that helps to fill the newly acquired adipocytes. While building and maintaining bone structure may sound like a good idea to us, it is not pre-programmed into our genetic matrix.

Development of new fat cells has evolved as a protective mechanism, although the vast majority of older adults really don`t need this genetic advantage. Researchers found that supplemented resveratrol, vitamin D and quercetin work together to regulate our genes and down regulate the production of fat cells while boosting the production of osteoblasts. Naturally it is important to practice caloric restriction as we age. Many aging adults will be able to utilize this phytonutrient trio to prevent excess weight gain and the debilitating effects of osteoporosis.

Natural Nutrients Help Weight Management Efforts Along with Healthy Diet

In addition to the well documented anti-cancer and longevity benefits previously ascribed to supplemented resveratrol, health-minded individuals will want to include resveratrol and other phytonutrients as an aid in the fight against abdominal fat accumulation. Researchers concluded “It should be noted that combining resveratrol with other phytochemicals may provide an extraordinary potential for preventing obesity and osteoporosis. These phytochemical synergies may make possible novel safe, potent and efficacious therapies.” Be sure to include resveratrol (25 to 50 mg per day) in your dietary arsenal to assist weight loss, boost metabolism and prevent bone loss.

Blueberries, Resveratrol and Cocoa Assist Weight Management Goals

A wealth of new scientific evidence shines a critical light on the importance of natural foods and nutritional compounds in the fight against overweight, obesity and weight maintenance. Virtually all alternative health experts agree the current epidemic of weight control issues plaguing western society are the result of excess consumption of highly processed convenience foods that have replaced vegetables, fruits, nuts and seeds in the diet.

Three independent studies conclude that blueberries, resveratrol from red grapes and cocoa flavanols exert a potent effect on fat cell formation that can aid in weight loss and management goals when included as part of your daily diet.

Blueberries Inhibit the Formation of New Baby Fat Cells

Blueberries have been well documented for their cognitive and cardio-protective benefits, due in large part to the potent complex of anthocyanins that give the berry its deep blue color. Researchers reporting the results of a study to the Experimental Biology 2011 conference have found that blueberries may hold the key to resolving one of the largest threats to human health this century: overweight and obesity.

Scientists determined that extracts of the berry compound inhibited the formation of new baby fat cells (adipocytes) in a dose-dependent manner. Less adipocytes means there are fewer `containers` to store triglycerides from the blood, and ultimately a powerful mechanism to lower or help maintain body weight. Not only did blueberry extract supplementation reduce the number of adipocytes up to 73 percent, but the compound was also found to assist in the breakdown of lipids and fats for removal from the body.

Cocoa Polyphenols Slow the Breakdown of Carbohydrates to Fuel Weight Loss

Polyphenols from the cocoa plant have been shown to promote cardiovascular, skin and brain health in recent studies. Research published in the Journal of Agricultural and Food Chemistry provide evidence that extracts of the cacao bean, particularly the flavanol epicatechin is a potent inhibitor of enzymes that break down carbohydrates during digestion.

Study authors determined the compound exerted an effect in a dose-dependent fashion, noting “the more consumed, the greater the effect.” They were also careful to conclude that chocolate and cocoa are two very different terms with the distinction that cocoa is the non-fat component of cocoa liquor, and the carbohydrate-inhibiting effect is not seen when sugar-infused milk chocolate sources are used. A minimum cocoa content of 55% is necessary for health and weight management concerns.

Resveratrol, the bioactive compound found most commonly in the skins of red grapes is shown to reduce body fat formation by preventing the formation of fat tissue in a study published in the journal Nutrition and Metabolism. The compound is known to positively affect cognitive functions and extend natural lifespan by regulating the longevity gene SIRT1. Researchers explain that ingesting resveratrol at supplemental doses (50 mg per day) for a period of six weeks caused a significant reduction in the activity of enzymes linked to fat production in the body.

Effective weight loss and management requires a combination of lifestyle and dietary modifications. Natural foods and dietary nutrients such as blueberries, resveratrol and cocoa compounds provide a safe and powerful mechanism to achieve long-term weight reduction goals.

Grape Seed, Resveratrol and Pomegranate Significantly Lower Blood Pressure

Adults aged 55 and older face a lifetime risk of developing elevated blood pressure greater than 90%, accounting for more than 40 million doctor visits each year and taxing an already overburdened healthcare system. Uncontrolled blood pressure slowly degrades the vascular system throughout the body and takes a particular toll on the kidneys, eyes and delicate arteries around the heart and in the brain.

Small increases in blood pressure place an individual at dramatically increased risk from heart attack, stroke, kidney failure and blindness. Researchers focusing on the antioxidant capacity of grape seed, resveratrol and pomegranate found that regular consumption of these foods can effectively reduce blood pressure without the need for dangerous prescription drugs.

Natural Fruit Polyphenols Lower Cellular Stress and Blood Pressure

Oxidative stress is a significant factor leading to accelerated damage from hypertension. Excess stress prompts changes to the hormone angiotensin that is known to impact blood pressure through an intricate mechanism of vessel and arterial constriction. Natural agents that can lower dangerous levels of cellular oxidative stress are considered paramount to lowering blood pressure in susceptible individuals.

ACE (angiotensin-converting enzyme)-inhibitors are among the most popular prescription medications prescribed to negate the effect of the angiotensin hormone, and create a life of misery for many due to the myriad of side effects inherent with this class of drug. Recent research shows that artificially lowering blood pressure with drugs has virtually no effect on cardiovascular disease risk, compared to lowering readings with natural fruit polyphenols, diet and physical activity.

Study Shows That Grape Seed Extract and Resveratrol Can Effectively Lower Blood Pressure

Writing in the journal Metabolism, nutritional scientists compared the effect of grape seed extract and resveratrol on subjects with metabolic syndrome. Three groups were divided to receive either grape seed extract (GSE) at a dose of 150 mg per day, GSE at 300 mg per day or a placebo. After 4 weeks, both GSE supplemented groups experienced systolic blood pressure drops of 5 to 7 percent. This change was considered significant as no other dietary or lifestyle interventions were followed. Researchers believe that GSE and grape-derived compounds including resveratrol can be used to prevent and treat hypertension based on the potent antioxidant load delivered by the fruit extracts.

Pomegranates effectively lower blower blood pressure in a manner similar to GSE and resveratrol as the juice and extracts contain powerful polyphenols that counteract oxidative stress. This magical fruit also is found to lower circulating levels of the angiotensin hormone that can help blood vessels to relax. The result of a study published in the journal Atherosclerosis demonstrated that consumption of pomegranate juice (50 ml per day for 2 weeks) lowered ACE activity by 36%, leading to a 5% drop in systolic blood pressure.

It should come as no surprise to those following a natural health lifestyle that the key to controlling blood pressure and reducing the risk factors that promote cardiovascular disease are not found in a prescription bottle. Fruits such as the pomegranate and formulated natural extracts from red grape skins and seeds deliver powerful health benefits without any of the associated side effects of synthesized pharmaceuticals.

Resveratrol and Grape Seed Extract Help Prevent Diabetes

Researchers publishing the results of two independent studies in the British Journal of Nutrition have demonstrated that polyphenol antioxidants found naturally in red grapes can prevent the buildup of fat in muscle tissue that is a precursor to metabolic disorder and diabetes. Resveratrol and grape seed extracts influence how the body responds to insulin, the hormone that controls critical mechanisms of dietary sugar and fat metabolism.

The grape-derived compounds have been shown to improve cardiovascular and Alzheimer`s disease risk factors in the past. Information gleaned from these studies explains how daily consumption of the fresh fruit can be invaluable as it prevents muscular fat accumulation leading to metabolic instability and diabetes.

High Sugar Diet Leads to Fat Accumulation in Muscle Tissue

Detailing the result of research performed at the University of Montpellier in France, scientists found that subjects fed a diet high in fat and sugar experienced a lower accumulation of fat in muscle tissue when supplemented with a concentrated extract of red grape polyphenols. Diets high in oxidized saturated fats are known to disrupt the normal function of insulin leading to insulin resistance and diabetes. By limiting the effect of fats on cell membranes, the grape extract was found to provide a significant level of protection against the disease.

In a separate body of research, scientists determined that a 10 mg daily dose of resveratrol was associated with lowered insulin resistance in Type-II diabetics. Resveratrol is a powerful protective anti-fungal compound found in the skin of red grapes. Known to activate a longevity signaling gene (SIRT-1), resveratrol has been shown to extend lifespan by lowering the risks associated with systemic inflammation. The polyphenol may help to prevent cancer development, cardiovascular disease and dementia, and is now shown to impede the development of diabetes by regulating insulin sensitivity.

Resveratrol Improves Insulin Sensitivity to Prevent Metabolic Syndrome and Diabetes

Researchers formed two groups of participants and randomly supplemented their diet with resveratrol (5 mg twice a day) or a placebo. After four weeks the resveratrol group showed a significant decrease in insulin sensitivity compared to the placebo group. The study authors explain that the results are likely due to the potent antioxidant action of resveratrol, as oxidative stress is a key contributor to the onset of insulin resistance.

Researchers concluded “The present study shows for the first time that resveratrol improves insulin sensitivity in humans, which might be due to a resveratrol-induced decrease in oxidative stress that leads to more efficient insulin signaling.” To maximize the anti-diabetic health benefits of grape polyphenols, health-minded individuals will want to include organically grown red grapes in their diet or supplement with grape seed extract and resveratrol (10 to 25 mg daily).

Resveratrol and Curcumin Promote Cell Regulation to Lower Cancer Risk

Every cell in our body generates waste that must be removed to preserve normal function. This process is called autophagy and is known to decline in efficiency as we age. When excess cellular debris is allowed to accumulate in our cells, normal function is altered and the cell begins to deteriorate.

This paves the way for accelerated aging and chronic illnesses including heart disease, many cancer lines and neurologic disorders such as Alzheimer’s disease. Cutting edge research underscores the importance of natural nutrients such as resveratrol, curcumin, berries and leafy greens to induce autophagy and lower the risks associated with premature aging.

Resveratrol Triggers Natural Cellular Housekeeping

Resveratrol is a powerful nutrient that has been shown to directly influence genes that regulate metabolic mechanisms and promote longevity. In addition to mimicking the effect of calorie restriction, resveratrol is emerging as a compound that can be used to assist the removal of cellular debris and improve efficiency.

The result of a study published in the Impact Journal on Aging demonstrates how resveratrol triggers autophagy in otherwise dormant cells. Resveratrol is shown to activate a series of proteins known as SIRT 1 that protect the delicate functional structures within the cell body and stimulate waste removal. This action effectively sets off a chain of events that leads to improved cellular efficiency and anti-aging characteristics.

Curcumin is a Powerful Anti-Cancer Agent

Curcumin has a long history as an effective weapon in the fight against cancer and as an anti-aging nutrient. Derived from curry powder, curcumin has been shown to initiate normal cell death in abnormal cancer cells in a process called apoptosis. The nutrient works on cellular DNA to stimulate the removal of waste debris and can target precancerous tumor cells to undergo programmed destruction.

Information published in the British Journal of Cancer explains that curcumin targets several death pathways in cancer cells that can become disabled, allowing uncontrolled growth and proliferation. Researchers found the curry extract to be particularly effective in cancers of the digestive tract and esophagus and concluded, “it is likely that curcumin and indeed some of its bioavailability-enhanced analogues are realistic options to be considered in the future for targeted molecular cancer prevention and treatment.”

Berries and Leafy Greens Found to be Neuroprotective

Blueberries, strawberries and spinach are natural foods that exhibit a strong protective shield to the aging brain. An analysis published in The Journal of Neuroscience demonstrates the capacity of these super foods to induce autophagy. Berries and leafy greens are packed with polyphenols and anthocyanins that convey powerful antioxidant and anti-inflammatory properties to these foods.

The study authors found that compounds in berries and spinach were able to cross the blood-brain barrier and directly influence the functional capacity of neurons. The lead study author noted “the findings from this research suggest that nutritional intervention with fruits and vegetables may play an important role in reversing the deleterious effects of aging on neuronal function and behavior.” 

Cellular housekeeping is an essential task that determines our rate of aging and risk of developing chronic disease. In addition to proper diet and regular exercise, health-minded individuals can take advantage of natural nutrients such as resveratrol and curcumin and foods like berries and spinach to maximize cellular autophagy and extend our natural lifespan.

Resveratrol and Grape Seed Activate Longevity Genes

(Article first published as Resveratrol and Grape Extract Shown to Extend Healthy Lifespan on Technorati.)

The benefits of calorie restriction have been known for the past 75 years and provide an important means to increase lifespan. Scientists continue to uncover the evolved biological mechanisms that have been shown to extend life and improve health in animals and mammals alike. 

Eating too much burdens our ability to properly metabolize such a large number of calories and raises the risk of disease. Excess energy from food also influences our genes that regulate aging. The good news is that you can experience the health benefits of calorie restriction by supplementing with targeted nutrients that mimic the effects of lowered calorie intake.

Reducing Calories by 25% Increases Lifespan

Our body is very sensitive to the amount of energy we consume from food each day and scientists have discovered a highly evolved set of genes known as silent information regulators (SIR) that control metabolism and influence our health in an effort to secure our survival. Reducing calories by a quarter has been demonstrated to increase lifespan and improve all aspects of aging including gene expression, DNA repair, oxidative stress and systemic inflammation.

The problem is many people are unable to reduce their food consumption enough to trigger the health boosting effects of calorie restriction. High calorie processed foods have become a large part of our diet that negatively impacts our genes through wild blood sugar swings, insulin resistance and lipid abnormalities. Researchers have found that natural chemical compounds which have evolved to protect fruits and vegetables are able to activate our SIR genes and replicate many of the age reversal effects of caloric restriction.

Resveratrol is a Powerful Antioxidant

Extensive research has documented the antioxidant properties of resveratrol as this polyphenol substance has been shown to prevent oxidative damage that fuels the aging process. The results of a study published in the journal Cell show how resveratrol improves the function of cellular powerhouses known as mitochondria by up regulating the action of the SIR genes. Researchers found that this provided protection against metabolic diseases such as diabetes and heart disease by decreasing oxidative stress on the cell.

Grape Seed Extract Absorbs Free Radicals

Every time you eat, walk or breathe you create free radicals as part of normal metabolism. These tiny particles wreak havoc on the cellular matrix of our cells and are particularly damaging to our brain. Grape seed extract has been shown to decrease free radical induced protein oxidation that affects the electrical conductivity of neurons in the brain. Information published in the Journal of Agricultural and Food Chemistry document the ability of grape seed extract to modify genes which control brain inflammation and may improve cognitive function and memory.

Quercetin Reduces Systemic Inflammation

Quercetin is super nutrient found in many fruits and vegetables that has been shown to exert influence on our genes that control the release of inflammatory chemicals known as cytokines in our body. Cytokines increase levels of inflammation and are known to cause damage to the vascular system and play a role in cancer initiation. A diet high in fresh vegetables and leafy greens will ensure that you consume this valuable nutrient in your diet, although it may be necessary to supplement to attain optimal benefit.

Nature has provided us with a host of nutrients that directly influence our genes and cellular function. Calorie restriction is a proven method to alter our genes toward improved health and longevity. While everyone may not be able to control calories, we can take advantage of natural nutrients that provide similar benefits.

Pomegranate and Super Nutrients Assist Weight Loss

(Article first published as Pomegranate and Natural Nutrients Can Help Prevent Weight Gain on Technorati.)

As the rate of overweight and obese individuals continues to rise with no end in sight, there’s good news emerging about the power of natural nutrients such as pomegranate that act on a genetic level to halt the accumulation of abdominal fat. Many people are aware that they need to lose weight but can’t seem to make the necessary lifestyle and dietary adjustments that will help them achieve their goal. Pomegranate and other natural nutrients may provide the key as they can be used to compliment healthy diet and physical activity toward your weight loss goal.

Pomegranate Shown to Reduce Belly Fat

Pomegranate is truly a super nutrient as it has been shown to clear dangerous blood fats known as triglycerides before they are converted to a form of fat which can be stored in our fat cells. This is important because lowered triglycerides have been shown to reduce the risk for heart disease and death from a heart attack.

Excess triglycerides form in the blood in response to a diet high in refined, processed carbohydrates and hydrogenated fats. The results of a study performed at the University of Edinburgh and reported by the Daily Mail confirms that pomegranate consumption for a period of 30 days was sufficient to lower the risk of developing fatty cells around the abdomen. Researchers note that this type of fat accumulation is the most dangerous type as it causes the release of stress hormones which fuel inflammation and promote heart disease.

Resveratrol Mimics Calorie Restriction

Resveratrol has gained acclaim as a super nutrient that has been shown to function at the genetic level by influencing genes known as SIRT’s which we have evolved through a sophisticated mechanism designed to keep us alive during times of famine. Our survival genes have the opposite effect when we overeat, as they fuel the aging process and no longer effectively protect us from disease.

Resveratrol is one of the few nutrients which can directly regulate the SIRT genes and mimic calorie restriction without having to eat less. This powerful compound found in the skin of red grapes switches the genes that control the release of dangerous chemical messengers from our fat cells in response to excess weight, and naturally promotes weight loss when combined with a reduced calorie diet.

Quercetin Lowers Systemic Inflammation

The fat cells of overweight and obese individuals is metabolically active and releases a steady stream of chemical messengers known as cytokines which circulate throughout the body and lead to chronically elevated levels of inflammation. This dangerous condition makes weight loss much more difficult and also is a known risk factor for heart disease and cancer.

Quercetin is a natural agent found in many fruits and vegetables that has a demonstrated ability to lower inflammatory cytokines by acting directly on the genes that produce these damaging compounds. By damping the flames of inflammation, quercetin is able to reduce the risk of many deadly diseases and assists natural weight loss by creating an environment which encourages fat metabolism.

Nature has provided a host of natural nutrients which we can combine with healthy diet and physical activity to improve health and achieve our weight loss goals. Pomegranate is the latest addition to the list of powerful nutrients that have been shown to regulate our genes and influence our ability to burn stored fat.

Resveratrol is Key to Anti-Aging and Assists Weight Loss Efforts

(Article first published as Is Resveratrol the Key to Anti-Aging and Natural Weight Loss? on Technorati.)

Resveratrol is the protective bioactive nutrient found most commonly in the skin of red grapes, peanuts and cacao. Resveratrol provides a protective barrier against disease and fungus in plants which is also beneficial to human health. A wealth of information exists to support the function of resveratrol for brain rejuvenation, cardiovascular repair as well as influencing the metabolism of fat leading to natural weight loss.

Resveratrol Improves Endothelial Function Leading to Heart Health

Proanthocyanadins from the grape family have long been associated with heart health, and resveratrol now takes its deserved place at the top of the cardiovascular friendly nutrients list. The lining of the cells within the artery are known as the endothelium, and are very sensitive to dietary abuse caused by hydrogenated fats, excess sugar, cortisol and insulin. Damage to the endothelium leads to high blood pressure as well as micro cracks which are filled with foamy plaque, increasing the risk of heart attack.

The results of a peer reviewed study published in the online journal PLoS One, resveratrol was found to be a natural anti-aging agent and exhibited many of the same characteristics as calories restriction. This natural defense nutrient is able to act at the genetic level to influence genes which promote cardiac dysfunction and glucose metabolism. In addition to assisting weight loss goals, resveratrol can help to prevent heart disease, stroke and diabetes.

Resveratrol Activates New Brain Synapses

One of the most important functions attributed to resveratrol is the activation of the anti-aging gene known as SIRT1. Previously, calorie restriction was the only known mechanism thought to positively influence this critical gene, but recent research demonstrates that resveratrol is also able to accomplish this longevity function. Since resveratrol is able to cross the blood-brain barrier, it is able to improve brain plasticity by generating new neural networks.

Resveratrol has been shown to reduce the normal rate of neurodegeneration while preventing memory impairment. Further, resveratrol has been shown to increase brain oxygenation which relates to increased memory capacity and improved cognition. Researchers are exploring the possibility that this amazing nutrient may play a role in the prevention of certain dementias, including Alzheimer’s disease.

Resveratrol Inhibits the Formation of Fat Cells

Resveratrol has been shown to halt the formation of baby fat cells, thus providing an effective tool for the millions of people looking for a natural weight loss aide. Researchers demonstrated that fat cells make SIRT1 in direct proportion to the amount of resveratrol they are exposed to. SIRT1 halts the formation of immature fat cells which as they grow, contribute to the accumulation of dangerous abdominal fat.

Resveratrol also lowers levels of systemic inflammation which is implicated in many afflictions including heart disease, diabetes, cancer and Alzheimer’s, and inhibits the release of body fat from storage. Studies underscore the importance of resveratrol as an important tool in the fight against obesity, and show that it can provide favorable metabolic stability to assist weight loss.

It’s rare when one specific nutritional compound is attributed with the potential to lower the risk of multiple disease processes and assist weight loss. Resveratrol continues to fill the promise of cardiovascular and neurologic health as it directly influences the anti-aging SIRT1 gene, and provides support in the battle against obesity. Health conscious individuals will use this critical nutrient in a never ending battle to provide an edge against time, ageing and cellular deterioration.