Omega-3 Fats Found in Fish Oil Boost Immune Response to Help Fight Inflammation and Disease

Most people take a healthy immune response for granted, as it typically remains on guard detecting a host of known and as yet unidentified pathogens that may threaten our health. Bacteria and viruses that cause the common cold, flu, digestive distress and a variety of potentially fatal illnesses are identified and destroyed before they cause more than a minor discomfort. For most of the past decade, fish consumption and supplementing with DHA and EPA fortified supplements has been shown to lower levels of systemic inflammation and significantly reduce the risk of developing many cancers, stroke and cardiovascular disease, yet the precise mechanism of action has been unknown.

Fish Oil Fats, DHA and EPA Stimulate Immune System B cells to Fight Inflammation and Disease Risk

A group of researchers from the Department of Food Science and Human Nutrition at Michigan State University have published the result of their work in the Journal of Leukocyte Biology that shows how DHA-rich fish oil enhances B cell activity, a white blood cell that is critical to activate our immune response. One of the study authors, Dr. Jennifer Fenton explained “Fish oil may have immune enhancing properties that could benefit immunocompromised individuals.”

Omega-3 fat sources including fish oil include the long chain fatty acids, DHA and EPA that have been shown in a number of prior studies to reduce total body inflammation that help to lower the risk of developing many chronic illnesses including cancer, heart disease, dementia and stroke. Researchers now uncover how these special fats enhance B-cell activity, a white blood component necessary to improve immune system activity and lower inflammatory response.

Supplement Daily with A Distilled Fish Oil Capsule to Squelch Inflammation and Lower Disease Risk

Researchers used two mouse models to conduct their study, one group was fed a control diet and the other was fed a diet supplemented with DHA-rich fish oil for a period of five weeks. B cells were taken from various tissues and the scientists then looked for markers of B cell activation on the cell surface, B cell membrane changes, and B cell cytokine production to assess immune response activation.

The team found that those mice supplemented with DHA-enriched fish oil demonstrated B cell activation and antibody production to aid immune response and pathogen clearance, while damping systemic inflammation. The authors concluded “This work confirms similar findings on fish oil and B cells… and moves us one step closer to understanding the immune enhancing properties of EPA and DHA.” Adults should supplement with a distilled fish oil preparation (1,200 to 2,400 mg EPA/DHA per day) to fight inflammation and heighten immune system response.

Omega-3 Fats Slash Inflammation to Fight Cancer and Heart Disease

It is a commonly accepted fact within the medical research community that systemic inflammation is a primary cause of many forms of cancer, heart disease and other chronic diseases that take the lives of millions well before their time. Poor diet, stress and lifestyle factors all contribute to inflammation that overworks body metabolism and encourages damage to the delicate vascular system that feeds our heart. Production of inflammatory chemical markers such as cytokines are accelerated over months and years of exposure that creates an environment known to encourage the spread of cancer cells and propagate cardiovascular disease.

Two independent studies published in the American Journal of Clinical Nutrition have found that supplementing Omega-3 fats lowers the release of inflammatory biomarkers that are involved in damage to cells called soluble adhesion molecules. Researchers have demonstrated that Omega-3 fats from fish oil supplements effectively lower levels of circulating adhesion molecules to decrease risk of atherosclerosis and counteract the pro-carcinogenic action of these damaging compounds produced by long-term inflammation throughout the body.

Omega-3 Fatty Acids Inhibit Adhesion Molecules to Lower Heart Disease Risk
To prepare their work, researchers conducted a meta-analysis on eighteen separate studies that examined the effect of soluble adhesion molecules (sICAM-1) and Omega-3 fats and their impact on systemic inflammatory markers in the body. The results showed that Omega-3 supplements were associated with sICAM-1 reductions in both healthy people and subjects with abnormal blood lipid levels.

The scientists commented “This finding suggests that omega-3 PUFA reduces inflammation by selectively inhibiting monocyte activation rather than endothelial activation… and supports the notion that omega-3 PUFA can be supplemented to prevent the development and progression of atherosclerosis.” The Omega fats were found to lower levels of oxidized LDL cholesterol molecules and decrease particle size, both factors known to lower cardiovascular risk. The fats were also found to inhibit platelet aggregation or clumping and resolve particle adhesion properties to allow blood to flow freely through the vascular arteries.

Eat Fish Three Times Each Week or Supplement Daily with Distilled Fish Oil
A second research study performed in France determined that Omega-3 fats lower breast and prostate cancer risk in a cohort of 408 individuals with the disease, compared to 760 healthy control subjects. The scientists found a direct correlation between cancer development and Omega-3 supplementation, again by inhibiting the expression of adhesion molecules required for cancer cells to propagate.

Oily fish is the natural food source for pre-formed DHA and EPA Omega-3 fats. Many people avoid fish due to mercury contamination and unknown harvesting methods, making supplementation with a moleculary distilled form a viable option. Plant-based Omega-3 sources such as walnuts and flax seeds do not provide a good source of the necessary pre-formed long-chain fats, and while they are very healthy foods, do not yield a reliable supply of EPA and DHA fats. Read supplement labeling for a brand yielding 1,200 to 2,400 mg each day of combined EPA/DHA Omega-3 fats to lower the risks associated with heart disease and cancer.

Omega-3 Fats are Essential to Prevent Nerve Damage after Traumatic Injury

People that have suffered a traumatic injury face an uphill battle as they attempt to regain their health and fight the risk of depression as a long term consequence of the event. British researchers from Queen Mary at the University of London have published the result of a study in the Journal of Neuroscience that explains how omega-3 fatty acids play a significant role in preventing and protecting nerves from injury.

The research focused on peripheral nerve cells which transmit signals between the brain and the spinal cord to the rest of the body. Omega-3 fats from food sources including sardines, salmon, walnuts and flaxseeds provide for decreased cell death from injury and may offer significant protection against future damage.

Omega-3 Fats Help Prevent Nerve Damage and Assist the Repair Process

Current research indicates that our nerves do have a limited capacity to regenerate, but recovery is severely limited depending on the extent of the injury. Omega-3 fatty acids are essential for the body's normal growth and development and have been well researched for their health benefits, largely focused on brain and heart health. The body is unable to manufacture its own Omega-3 fat supply, so it is necessary to obtain sufficient intake from foods such as oily fish, nuts and seeds or through supplementation.

Researchers studied the effect of Omega-3 fats on isolated mice nerve cells, known to parallel human nerve responses. They simulated nerve damage caused from an accident or injury by either stretching the cells or starving them of oxygen. Both types of damage can kill a significant portion of nerve cells, but enrichment with omega-3 fatty acids in cells gave them significant protection and decreased cell death.

EPA and DHA Fats Lower Sciatic Nerve Injury Damage and Prevent Muscle Wasting

The study also examined sciatic nerve damage in the mice. They found that a high level of omega-3 fatty acids helped mice to recover from sciatic nerve injury more quickly and more fully, and that their muscles were less likely to waste following nerve damage. The team leader, Dr. Adina Michael-Titus, Professor of Neuroscience concluded “Our previous research has shown that these fatty acids could have beneficial effects in a number of neurological conditions. This new study suggests that they could also have a role in treating peripheral nerve injuries.”

The findings from this research should come as no surprise to integrative health followers. The Omega-3 fats EPA and DHA are essential building blocks to all cellular structures in the body and are particularly dominant in the brain and nervous system. A healthy supply of Omega-3 fatty acids allows for natural cell repair and the effective chemical and electrical communications that are important to optimal nerve function. Consuming fatty fish three to four times a week or supplementing with molecularly distilled fish oil (1 to 2.4 grams total EPA/DHA) supports the nervous system and regeneration process after injury.

B Vitamins and Omega-3 Fats Slow Alzheimer’s Disease Progression

Proper nutritional status attained by consuming a healthy diet teaming with natural vitamins and minerals along with optimization of omega fat lipid ratios can help to prevent cognitive decline associated with Alzheimer’s disease (AD) pathology. Researchers studying the effects of nutrition at Oxford University in England found that daily supplementation with folic acid and vitamins B6 and B12 lowered levels of homocysteine, a known risk factor leading to decline in cognition and memory.

Further evidence published in the journal Molecular Nutrition & Food Research explains that a disproportionate ratio of omega-6 to omega-3 fatty acids plays a crucial role in the development of AD in later life. Cellular nutritional saturation from diet and appropriate supplementation with B vitamins and omega-3 fats may provide the cornerstone to prevent this most feared memory-robbing disease.

B Vitamin Supplementation Shown to Lower Homocysteine by 30% and Slow Brain Atrophy

Reporting in the International Journal of Geriatric Psychiatry, scientists examined the proposed link between elevated homocysteine levels and cognitive decline. Homocysteine has already been shown to dramatically increase the risk of heart disease and heart attack in prior studies. Researchers examined 266 people over the age of 70 with established mild cognitive impairment, and broke them into two groups. One group was supplemented with folic acid, vitamin B6 and B12, vitamin cofactors that lower homocysteine levels, while the second group received a placebo.

Brain wasting or atrophy is a common sign of cognitive impairment and is closely associated with Alzheimer’s dementia. The rate of brain atrophy is increased by higher concentrations of homocysteine in the blood and brain tissue. Researchers examining the results of this study found that the group supplemented with B vitamins for a period of two years experienced a 30% reduction in homocysteine levels. They found dramatic improvements in mental tests including global cognition and episodic memory (69% improvement in word recall memory) compared to the control group.

Omega-6 to Omega-3 Fat Ratio in Diet Creates an Imbalance in the Brain

The standard American diet (SAD) includes large quantities of oxidized omega-6 fats from fried and processed foods when compared to omega-3 fat consumption (from fish, nuts and seeds). The ratio of omega-6 to omega-3 fatty acids ranges from 20:1 to as high as 50:1 (ideal range is no more than 4:1), creating a perpetual degree of inflammation throughout the body. Researchers have determined that this imbalance creates a disturbance in brain chemistry affecting neurotransmitter balance and electrical firing in the brain that sets the stage for amyloid tangles and cognitive decline.

Reestablishing omega fat homeostasis by balancing toward a 1:1 intake ratio and correcting B vitamin nutritional deficiencies provide deep insight toward understanding and controlling risk factors for the development of many forms of dementia including Alzheimer’s disease. Most middle aged adults will want to include a high potency B vitamin supplement (preferably formulated from natural food sources) and include omega-3 fats from diet or fish oil consumption to lower dementia risk factors.

Green Tea and Fish Oil Promote Health and Assist Weight Loss

Green tea and the Omega-3 fatty acid DHA combine to provide a powerful natural shield against certain forms of cancer, heart disease, stroke and dementia while assisting weight loss and maintenance. Both of these nutrients directly target gene sequences which have been shown to lower disease risk while increasing base metabolism to burn more calories.

Include green tea and DHA in your nutritional arsenal to prevent a wide array of potentially lethal illnesses and reach your ideal weight loss goal.

Harness the Power of Green Tea Against Cancer

The active antioxidant compound in green and white tea is Epigallocatechin gallate (EGCG) which has been shown to exert significant anti-cancer properties by fighting development and proliferation of rogue cells. EGCG works by switching off the genes responsible for cancer initiation while influencing natural cell death to prevent replication. Chemical components of green tea further help to cut off the blood supply cancer cells need to grow while lowering levels of dangerous systemic inflammation known to promote cancer as well as many other diseases.

Green Tea Boosts Metabolism

The results of a study published in the European Journal of Clinical Nutrition provide evidence that EGCG increases fat oxidation by 33% through accelerated metabolism. Green tea has also been shown to inhibit fat cell formation and improve excretion of fat from abdominal adipose tissue. This study found that fat was burned at a higher rate for 2 hours after eating and deceased rapidly after that point. The study authors recommend drinking green tea or supplementing with EGCG prior to eating for maximum benefit.

The researchers also noted that higher intake of green tea or EGCG does not necessarily translate into increased levels of fat oxidation. Fresh brew your own green tea or use low dose EGCG supplements (300 mg or less) to receive the full fat metabolism effect.

DHA Provides Support for the Heart and Brain

DHA is one of two Omega-3 fats found in fish and distilled fish oil. DHA has been shown to lower levels of inflammation, provide a thinning effect to blood platelets to prevent clotting and reduce dangerous triglycerides in the blood. These benefits all contribute to the heart health benefits of DHA as research demonstrates that supplementation can cut the risk of sudden death from a heart attack by one-third.

DHA is the preferred fat used in brain cell neurons as well as most other cells in the body. Its unique properties allow for oxygen and nutrients to easily pass through the cell wall. When this vital fat is deficient, other fats must be used which create a stiffer cell membrane leading to cellular death and disease.

DHA Prevents Fat Accumulation

DHA works by influencing genes which control blood sugar, insulin secretion and fat accumulation. This Omega-3 fat targets the bioactive white adipose cells and affects how triglycerides in the blood are either burned for fuel or allowed to be stored as fat. The results of a study published in the International Journal of Obesity demonstrate the addition of DHA and Omega-3 fats increased weight loss in a group of overweight men by 28% compared to those who didn`t supplement.

It’s no surprise that natural nutrients and supplements act to promote health and assist weight loss. Green tea and DHA fats are prime examples of an intricate mechanism evolved over generations which our body uses to support our health. Incorporate these powerful nutrients into your lifestyle for improved quality of life and longevity.