EGCG from Green Tea Blocks the Formation of Plaques to Help Prevent Alzheimer’s Disease

As new cases of Alzheimer’s disease are expected to quadruple over the next several decades, Big Pharma researchers are plowing billions of research dollars into finding a synthetic cure for an illness that has its roots deeply seated in poor diet, excess stress and a generally unhealthy lifestyle. Unfortunately for the giant pharmaceutical concerns, drugs have yielded nothing but dismal results as one potential miracle cure after another fail to provide any hope as new cases of the mind-robbing disease continue to mount.

Green Tea Consumption Prevents Protein Tangles that Promote Alzheimer’s Disease Progression

For more than a decade, nutrition scientists have been heralding a small number of natural compounds including resveratrol, curcumin and EGCG from green tea extracts that easily cross the blood-brain barrier to promote brain health and improve cognitive function. Researchers from the University of Michigan Life Sciences Institute, publishing in the Proceedings of the National Academy of Sciences, explain how extracts from green tea may block the formation of beta-amyloid plaques that have been linked to the onset of Alzheimer's disease and other neurodegenerative conditions that prevent the misfolding of specific proteins in the brain.

Improper accumulations of proteins known as metal-associated amyloids are a hallmark sign of many neurological conditions, including Alzheimer’s dementia. Researchers used green tea extract to control the generation of metal-associated amyloid-beta aggregates associated with Alzheimer's disease. Building on a volume of prior studies suggesting a protective role for regular green tea consumption, the team set out to establish a beneficial relationship between the active compound in green tea (epigallocatechin-3-gallate, also known as EGCG) and the formation of amyloid plaques.

Drink Three to Five Cups of Green or White Tea Daily to Help Fight Alzheimer’s Disease

The scientists determined that EGCG prevented the formation of amyloid tangles by preventing protein misfolding, and broke down existing aggregate structures in the proteins that contained metals, specifically copper, iron and zinc. Referring specifically to the bioactive catechin, EGCG, lead study author Dr. Mi Hee Lim concluded “A lot of people are very excited about this molecule… we want to modify them for the brain, specifically to interfere with the plaques associated with Alzheimer's”.

Nutrition experts note that green tea contains thirty to forty percent of water-extractable polyphenols while highly oxidized black tea contains between three and ten percent. White tea has undergone less oxidation than green tea and provides the most potent dose of EGCG catechins. A wealth of scientific evidence supports drinking three to five cups of green or white tea every day to support cardiovascular health and prevent protein aggregates in the brain that significantly increase Alzheimer’s disease risk.

Scientists Explain How Vitamin D and Omega-3 Fats Synergistically Prevent Alzheimer’s Disease

Alzheimer’s disease is characterized by a loss of short term memory, cognition and thought processes that define the personality of a person, and new cases are exploding exponentially. Though allopathic physicians and researchers maintain there is no known cause or treatment for the ultimately fatal illness, alternative practitioners understand the etiology has evolved from decades of living an unhealthy lifestyle. Dietary transgressions, exposure to cosmetic and household pollutants, lack of physical activity and long-term nutritional deficiencies all combine to promote Alzheimer’s disease development and progression.

A group of scientists have published the findings from their research in the Journal of Alzheimer’s Disease that has pinpointed how vitamin D3 and omega-3 fatty acids may enhance the immune system's ability to clear the brain of amyloid plaques. Researchers identified key genes and signaling networks regulated by vitamin D3 and the omega-3 fatty acid DHA (docosahexaenoic acid) that may help control inflammation and improve plaque clearance.

Vitamin D3 and DHA boost immune response to help prevent amyloid protein tangles

Prior studies have identified the loss of normal ability to break down amyloid proteins before they develop into tangles or plaques as a key process in the development of the memory-robbing disease. Lead study author, Dr. Milan Fiala from the David Geffen School of Medicine at UCLA commented “Our new study sheds further light on a possible role for nutritional substances such as vitamin D3 and omega-3 in boosting immunity to help fight Alzheimer's.”

To perform their study, scientists drew blood samples from both Alzheimer's patients and healthy controls and then isolated critical immune cells called macrophages from the blood. Macrophages are responsible for splicing the amyloid proteins before they can aggregate around the nerve synapse, effectively stifling electrical and chemical transmissions throughout the brain. Scientists then incubated the immune cells with amyloid-beta and added either an active form of vitamin D3 or the omega-3 fatty acid DHA to gauge effectiveness on inflammation and amyloid-beta absorption.

Supplement daily with Vitamin D3 and Omega-3 Fats to Slash Alzheimer’s Disease Risk

The researchers determined that vitamin D3 and DHA greatly improved the clearance of amyloid-beta by macrophages in patients with Alzheimer’s disease, and found subtleties in the effects the two substances had on the expression of inflammatory genes. The study team concluded “We may find that we need to carefully balance supplementation with vitamin D3 and omega-3 fatty acids, depending on each patient in order to help promote efficient clearing of amyloid-beta…. this is a first step in understanding what form and in which patients these nutrition substances might work best."

The study team observed that each nutrient (vitamin D and DHA) utilized different receptors and common signaling pathways to prevent amyloid protein aggregation leading to disease. Optimizing vitamin D blood saturation levels and supplementing with a molecularly distilled DHA omega-3 formulation can provide critical support in helping the brain to properly clear amyloid metabolic byproducts and help prevent Alzheimer’s dementia.

Active Compounds in Green Tea and Red Wine Halt Alzheimer’s Disease Progression

Alzheimer’s disease is characterized by an unnatural accumulation of amyloid plaque aggregates around nerve synapses that block the transmission of electrical and chemical transmitters that allow the brain to retain a high level of cognitive function and to store and retain memories. Millions of middle aged and older Americans suffer from some stage of Alzheimer’s disease, as the illness continues to escalate at an epidemic rate. It is projected that the prevalence will nearly quadruple in the next 50 years, by which time approximately 1 in 45 Americans will be afflicted with the disease.

Green Tea and Red Wine Extracts Impede Amyloid Formation to Prevent Alzheimer’s Development

The past decade has uncovered a small handful of natural, bioactive compounds that easily cross the blood-brain barrier where they have been found to alter the progression of Alzheimer’s disease. Researchers from the University of Leeds in the UK have determined that natural chemicals found in green tea and red wine may disrupt a key step of the Alzheimer's disease pathway. Publishing in the Journal of Biological Chemistry, scientists have identified the process which allows harmful clumps of protein to latch on to brain cells, causing them to die.

Scientists understand that amyloid proteins in the brain clump together to form toxic, sticky balls of varying shapes. These amyloid balls latch on to the surface of nerve cells in the brain by attaching to proteins on the cell surface called prions, ultimately causing nerve cells to malfunction and die. Study co-author Dr. Jo Rushworth commented "We wanted to investigate whether the precise shape of the amyloid balls is essential for them to attach to the prion receptors, like the way a baseball fits snugly into its glove.”

Supplement Daily with EGCG and Resveratrol to Slow Disease Progression

The team wanted to determine if it was possible to prevent the amyloid balls from binding to prions by manipulating their shape and stop the cells from dying. Scientists formed amyloid balls in a test tube and then added them to human and animal brain cells. Study authors concluded "When we added the extracts from red wine and green tea, which recent research has shown to re-shape amyloid proteins, the amyloid balls no longer harmed the nerve cells.”

Researchers determined that the bioactive compounds in green tea and red wine (EGCG and resveratrol) distorted the shape of the amyloid balls, preventing them from binding with prions and disrupting cellular function. Complimentary studies have also determined that curcumin, the active compound in the curry spice turmeric, crossed the delicate blood-brain barrier to halt the advancement of dementia. Health-minded individuals should consume green tea and red wine or take standardized supplements regularly to help prevent the initial development and progression of Alzheimer’s disease.

Resveratrol May Help to Prevent and Even Treat Alzheimer’s Disease

Incidence of Alzheimer’s disease cases continue to explode at an unprecedented rate as processed food diets, overweight and obesity become the norm for middle and senior aged adults in the US and most western societies. By the year 2050, it’s projected that 13.2 million adults will suffer from this degenerative disease that ranks as the sixth leading cause of death, with many suffering early signs of the condition at earlier ages. Any natural compound that can be shown to prevent or even treat Alzheimer’s disease would be a potent therapeutic tool.

Resveratrol Confirm the Benefits of Resveratrol to Fight Alzheimer’s Disease

Researchers from Georgetown University Medical Center's Memory Disorders Program have embarked on a mission to demonstrate that resveratrol can affect memory deterioration and daily functioning in people with mild to moderate dementia due to Alzheimer's disease. Resveratrol is a natural compound found in red grapes, red grape juice, red wine, chocolate, tomatoes and peanuts. In prior studies, the polyphenol has been shown to help prevent diabetes, act as a natural cancer fighter, ward off cardiovascular disease, and prevent memory loss.

As the risk of many chronic conditions increase with aging, resveratrol exhibits unique characteristics as it has been shown to impede telomere shortening and extend natural cell life and activity. Resveratrol has also been shown to improve glucose metabolism and insulin sensitivity, two mechanisms known to speed the aging process.

Supplement with Resveratrol Daily to Lower the Risk of Developing Alzheimer’s Dementia

Researchers will examine the direct impact of pure resveratrol supplementation on neural aging and amyloid protein clearance. Recent research has suggested that Alzheimer’s disease may result from insulin resistance specifically in the brain, and as resveratrol is known to cross the blood-brain barrier, the compound may prevent faulty insulin signaling that promotes the degenerative condition.

This is the largest and most extensive study of its kind developed to validate the brain health benefits of resveratrol. Researchers will recruit participants from 26 U.S. academic institutions that are affiliated with the Alzheimer's Disease Cooperative Study around the country. This study is unique because it is designed to demonstrate the impact of a natural compound and not a patentable pharmaceutical drug.

Resveratrol is supplied in small amounts from dietary sources including red grapes, red wine, chocolate and tomatoes. Nutrition experts recommend supplementing with a pure extract (20 to 500 mg per day) for optimal protection against Alzheimer’s disease and a myriad of chronic conditions.

Carnosine Protects Against Vascular Injury and Extends Lifespan

Most allopathic medical practitioners would argue that the process of aging is nothing more than a normal process whereby cells deteriorate at a predetermined rate controlled by genetically determined commands and heredity. Standing in stark opposition is a rapidly growing body of research and documented evidence to indicate that aging is a product of many varied lifestyle choices including physical activity, smoking and most importantly, the type of diet we regularly consume.

In addition to being a potent cellular antioxidant, carnosine exhibits a number of other unique capabilities that help limit glycation (the abnormal linking of proteins with glucose or lipids) to prevent injury to tissues and organ structures. These actions improve cardiovascular performance to protect against stroke, heart disease, dementia and increased susceptibility to cancer. Researchers publishing in the journal, Cellular Physiology and Biochemistry demonstrates that carnosine from supplements can help protect against a first stroke, and can significantly lower the damage caused by stroke.

Carnosine Binds with Zinc in the Brain to Prevent Abnormal Accumulation and Amyloid Tangles

Researchers have demonstrated that carnosine is particularly effective in providing multi-targeted protection to the heart and blood vessels through age-inducing processes such as oxidation, glycation, protein cross-linking, mitochondrial dysfunction, telomere shortening and heavy metal accumulation in tissues. Carnosine protects against ischemia or loss of blood flow to the heart muscle, preventing the devastating effect of reduced blood flow that leads to a heart attack.

A study team from the University of Glasgow in Scotland has released the result of their study in the journal Biochemistry to explain the importance of carnosine in the development and progression of cognitive decline and Alzheimer’s disease in aging adults. They noticed that dementia patients displayed lower levels of carnosine in their brains and spinal fluid than those of other older adults, and found that the condition results from multiple factors, virtually all of which have some connection to carnosine and its function in the brain.

Supplement Daily with Carnosine to Help Prevent Dementia, Heart Disease, Stroke and Diabetes

The researchers demonstrated that those parts of the brain that are first affected in early Alzheimer’s disease are the same in which carnosine is normally found in the highest concentrations. As carnosine levels fall with age, those brain areas become the most vulnerable to Alzheimer’s-related damage. Carnosine is known to bind with zinc in the brain, ushering them away from delicate tissues and preventing abnormal accumulation. Supplementation in known to increase blood levels and cellular saturation to halt protein cross-linking and the characteristic neurofibrillary tangles so frequently associated with the disease.

A growing number of forward-thinking scientists refer to carnosine as an “anti-aging dipeptide”, capable of defending against cardiovascular disease, stroke, diabetes, cognitive decline and dementia. Carnosine is readily available from high protein animal dietary sources including milk, eggs, cheese, beef, poultry and pork. Most health-minded individuals avoid these food sources for health and ethical reasons, and will want to supplement (500 to 1,000 mg per day) to shield against vascular disease and abnormal cellular aging.

Omega-3 Fatty Acids from Dietary Sources Lower Risk of Developing Alzheimer’s Disease

Omega-3 fats from foods including fish, chicken, nuts and seeds are preferentially sequestered after consumption and used for critical functions to maintain optimal brain metabolism and function. These long-chain fats are used to form the highly permeable cell wall membrane of nerve cells, as electrical and chemical transmissions through this barrier are limited when sufficient omega-3 fats are unavailable from blood circulation.

Researchers from the Columbia University Medical Center in New York have published the result of their work demonstrating the close relationship between Omega-3 fats, blood saturation levels of amyloid proteins and risk of developing Alzheimer’s disease in the prestigious journal, Neurology. The study confirms that lower blood levels of a protein related to Alzheimer's disease (amyloid-beta plaque) can protect against memory problems, mild cognitive decline and progression to Alzheimer’s disease in many cases.

Increased Omega-3 Fats from Diet Reduces Beta-Amyloid Levels in the Blood up to Thirty Percent

The lead study author, Dr. Nikolaos Scarmeas noted “While it's not easy to measure the level of beta-amyloid deposits in the brain in this type of study, it is relatively easy to measure the levels of beta-amyloid in the blood, which to a certain degree, relates to the level in the brain.” The brain normally generates amyloid proteins as a metabolic byproduct that are broken down and cleared in the youthful, healthy brain. The study suggests that Omega-3 fats from dietary sources can aid this process, though the scientists did not specifically note this conclusion.

Researchers looked at 1,219 people that were over the age of 65 and free of dementia. The participants provided information regarding their diet for an average of 1.2 years before their blood was tested for beta-amyloid. The scientists specifically monitored ten nutrients including saturated fatty acids, omega-3 and omega-6 polyunsaturated fatty acids, mono-unsaturated fatty acid, vitamin E, vitamin C, beta-carotene, vitamin B12, folate and vitamin D.

Consume Several Servings of Walnuts, Fish and Seeds Daily to Lowers Dementia Risk

The study determined that higher levels of omega-3 fats consumed by eating fish, chicken, nuts and seeds directly correlated to lower blood beta-amyloid levels. Researchers found that consuming one gram of omega-3 per day (equal to approximately half a fillet of salmon per week) was associated with 20 to 30 percent lower blood beta-amyloid levels. Researchers found that most people do not eat enough omega-3 enriched foods to adequately raise blood levels of the essential fat.

Dr. Scarmeas concluded “The more omega-3s one eats, the less the beta amyloid levels are… we were able to relate something that we eat with a very specific mechanism in the body that is very strongly related to Alzheimer’s.” This study did not account for intake of the pre-formed omega-3 fats supplied through fish oil supplements, known to dramatically boost blood saturation of the long-chain fats. Nutrition experts suggest several servings of fish, chicken, nuts and seeds each week (or supplementing with 1,200 to 2,400 mg EPA/DHA daily) to significantly lower the risk of developing Alzheimer’s disease.

Berry Consumption Lowers Risk of Cognitive Decline and Dementia in the Elderly

Incidence of cognitive decline leading to dementia and Alzheimer’s disease is rising at unprecedented levels among those aged 65 and older. Many people fear the myriad of memory-robbing forms of dementia more than a diagnosis of cancer. Blueberries and strawberries, which are high in flavonoids that easily cross the blood-brain barrier, have been shown to to reduce cognitive decline in older adults in prior bodies of research.

A new study recently published in the Annals of Neurology suggests that cognitive aging could be delayed by up to 2.5 years in elderly individuals who consume greater amounts of flavonoid-rich berries. In the past, studies have hinted at the positive effects of flavonoids from berry consumption, but have been limited to animal studies or very small sample groups. This is the first research to demonstrate the critical preventive and healing nature of anthocyanins in a very large cohort of more than 100,000 senior aged adults.

Blueberries and Strawberries Improve Cognitive Skills in Aging Adults

Flavonoids are bioactive structures found in plants that are known to have powerful antioxidant and anti-inflammatory properties. Nutrition researchers theorize that stress and inflammation contribute to cognitive impairment and that increasing consumption of flavonoids could thwart the harmful effects. Many forms of dementia, especially Alzheimer’s disease, are rapidly emerging as illnesses caused largely by poor lifestyle (environmental pollution, household chemicals and electromagnetic forces) and a highly processed diet consisting of sugar, glucose-stimulating carbohydrates and hydrogenated fats.

To conduct the study, researchers examined data from a cohort of 121,700 female registered nurses between the ages of 30 and 55 who completed health and lifestyle questionnaires beginning in 1976. Participants provided details about frequency of food consumption every four years, and cognitive function was measured in 16,010 subjects over the age of 70 years, at 2-year intervals.

Eat Three to five Servings of Fresh Berries Each Week to Lower Risk of Cognitive Decline

Researchers found that increased consumption of blueberries and strawberries slows cognitive decline by up to 2.5 years in older women. A greater intake of anthocyanidins and total flavonoids was also associated with a reduction in cognitive degeneration leading to Alzheimer’s disease. Lead study author, Dr. Elizabeth Devore concluded “Our study examined whether greater intake of berries could slow rates of cognitive decline.  We provide the first epidemiologic evidence that berries may slow progression of cognitive decline in elderly women. Our findings have significant public health implications as increasing berry intake is a fairly simple dietary modification for older adults.”

As aging adults fall prey to the processes of cognitive decline, dementia and Alzheimer’s disease at an unprecedented pace, it is comforting to know that there are a number of lifestyle and dietary steps that can be followed to improve brain health and memory loss. Include one to two daily servings from a wide variety of berries, especially blueberries and strawberries to improve cognition and normal brain function.

Regular Exercise and Active Lifestyle Lower Risk of Developing Alzheimer’s Disease

Scientific studies have previously demonstrated that many lifestyle factors as well as diet can have a major impact on genetic expression that either promotes of inhibits the development of Alzheimer’s dementia. Recent studies have demonstrated that insulin signaling and resistance in the brain result in the formation of amyloid protein tangles that are a hallmark of disease progression.

A new study by neurological researchers from Rush University Medical Center that will be published in the online journal of Neurology demonstrates that daily physical activity may reduce the risk of Alzheimer's disease and cognitive decline, even in people over the age of 80. Integrating a healthy diet including foods known to suppress sharp insulin and glucose spikes along with sensible supplementation (curcumin, resveratrol, grape seed extract and omega-3 fatty acids) and regular physical activity may be sufficient to halt Alzheimer’s progression as we age.

All Types of Physical Activity Found to Dramatically Lower Alzheimer’s Disease Risk

Lead author of the study, Dr. Aron S. Buchman noted “The results of our study indicate that all physical activities including exercise as well as other activities such as cooking, washing the dishes, and cleaning are associated with a reduced risk of Alzheimer's disease.” The study reinforced the concept of remaining physically active each day to ward off this devastating form of dementia.

Strenuous exercise is not essential and may hold potential health risks for the aging population. The key is to avoid becoming confined to a chair: keeping the muscles and brain active can dramatically alter brain chemistry and metabolism to prevent Alzheimer’s.

Lack of Physical Activity Nearly Triples the Risk of Developing Alzheimer’s Disease

To determine daily physical activity levels, researchers asked 716 older individuals without dementia and an average age of 82 to wear a device called an actigraph, a device attached to the wrist that monitors activity levels, for a period of ten days. Additionally, participants were given annual cognitive tests during this ongoing study to measure memory and thinking abilities. All types of physical activity from structured exercise sessions to common everyday tasks were recorded for analysis.

Over a three and a half year follow up period, 71 participants developed Alzheimer’s disease. Researchers determined that those individuals in the bottom ten percent of daily physical activity were more than twice as likely to develop Alzheimer's disease compared to those in the top ten percent. Further, the scientists found that those in the top ten percent as rated by physical intensity were nearly three times as likely to develop Alzheimer’s dementia, as compared to the lowest intensity group.

Dr. Buchman concluded “Our study shows that physical activity, which is an easily modifiable risk factor, is associated with cognitive decline and Alzheimer's disease.” This study adds to the mounting evidence that Alzheimer’s disease can be prevented by adopting a lifestyle of healthy eating, stress-reduction, minimized exposure to pesticides and toxins and engaging in daily physical activity.

Berries and Fruits Enhance Brain Signaling to Prevent Cognitive Decline and Promote Brain Health

Berry fruits including blueberries, blackberries and strawberries are not only refreshing and tasty, but they also provide a wide variety of phytonutrients that cross the blood-brain barrier to enhance neural communications and prevent oxidation and inflammation. This has beneficial effects on the brain and may help prevent age-related memory loss and other changes that alter behavior and cause normal thought processes to run askew.

Researchers reporting the result of a study in the Journal of Agricultural and Food Chemistry have identified neurological benefits associated with the consumption of berry fruits, including their now well-known antioxidant and anti-inflammatory effects. Eating the fruits in their natural state or using dietary supplements is shown to have dramatic direct effects on the brain in a meta-analysis of animal and human studies on the topic.

Fresh Berries Support Brain Health by Neutralizing Free Radicals and Lowering Inflammation

As we live longer, the toll of excessive oxidative assaults on the brain can result in loss of memory and cognitive decline as inflammation limits the electrical and chemical response within nerve synapses and cellular structures. A review of past studies demonstrated that consumption of berry fruits or standardized supplements can aid brain health in several ways.

Lead study authors, Dr. Barbara Shukitt-Hale and Marshall G. Miller from the Human Nutrition Research Center on Aging at Tufts University found that berries enhance neuroplasticity, neurotransmission, and calcium buffering, all of which lead to attenuation of age and pathology-related deficits in behavior. Berry fruits contain high levels of antioxidants, compounds that protect cells from damage by harmful free radicals. Suppression of free radicals was identified as a primary action of consuming the natural fruits.

Include Several Daily Servings of Fruits and Berries to Preserve Brain Health

Additionally, the researchers noted that berry fruits change the way neurons in the brain communicate. These changes in signaling can prevent inflammation in the brain that contributes to neuronal damage and helps to improve both motor control and cognition. The study confirmed the potent multimodal effect of berry consumption, but indicated that further studies would be required to determine if benefits are a result of individual compounds shared between berry fruits or whether the unique combinations of chemicals in each berry fruit simply have similar effects.

There is little doubt about the importance of including a wide array of berries in all shapes, sizes and colors to your regular diet. Nutritionists recommend eating at least one-half cup of the raw fruit each day to help prevent cognitive decline, loss of memory and Alzheimer’s dementia.

Chronic Stress Promotes Protein Brain Tangles and Risk of Alzheimer’s Disease

Alzheimer’s disease is characterized by an initial loss of short term memory and the ability to form rational and permanent thoughts. Protein tangles known as tau aggregates strangle neural synapses, blocking the vital flow of neurotransmitter and electrical signals necessary to form memories and personality. Once considered a disease of the aging, this form of dementia is increasing at a startling rate in younger individuals, largely due to a processed and refined food diet, environmental factors and long-term chronic stress.

Researchers from the University of California, San Diego School of Medicine have published the result of a study in the Proceedings of the National Academy of Sciences, explaining the mechanism behind continual exposure to stressors so common in our rapid-paced lifestyle, and the unnatural accumulation of insoluble tau protein aggregates in brain tissue. They explain that neurofibrillary tangles are one of the physical hallmark signs of Alzheimer’s disease, and have been shown to contribute to disease progression in people under chronic stress conditions during the course of past studies.

Chronic Stress is Positively Linked to Physical Brain Changes Leading to Alzheimer’s Dementia
The study team, using a mouse-based model, noted “we found that repeated episodes of emotional stress, which has been demonstrated to be comparable to what humans might experience in ordinary life, resulted in the phosphorylation and altered solubility of tau proteins in neurons… these events are critical in the development of NFT pathology in Alzheimer's disease.” Researchers determined that the effect was most pronounced in the hippocampus of the brain, an area linked to the formation, organization and storage of memories.

The scientists are quick to note that the type of stress that is associated with the development of tangles in the brain is not acute stress, defined as a single, passing episode. They determined that chronic, long term stress that never ceases is far more threatening to the brain and promotes tau protein aggregates to accumulate. Acute stress is actually considered useful for brain plasticity and helps to facilitate learning.

Engage in Stress Reduction Techniques to Reduce Stress and Disease Risk
Chronic stress continually stimulates and activates stress pathways in the brain that lead to pathological alteration of stress circuitry in the brain. The researchers describe chronic stress as too much of a good thing gone bad. Lead study author, Dr. Robert Rissman commented on their findings “As people age, perhaps their neuronal circuits do too, becoming less robust and perhaps less capable of completely rebounding from the effects of stress.”

Certainly we cannot entirely eliminate stress from our daily lives, and the results of this study conclude that small amounts of acute stress are important to maintain brain plasticity and for the formation of new memories. The problem arises when the level of stress never abates, and our brain is unable to recover from the massive amount of new stimuli we experience from chronic stress. Reduce your stress level to a minimum, as this will provide yet another crucial lifestyle modification that can help prevent chronic illness and ward off Alzheimer’s disease.

Vitamin D and Curcumin Synergistically Clear Brain Tangles to Prevent Alzheimer’s Dementia

New diagnosis of Alzheimer’s disease cases continue to mount at an unprecedented rate, threatening both the lives of those suffering from this dreaded illness and the health care system itself, as billions are spent to care for the millions suffering from this lifestyle-mediated disease. New hope is now offered by scientists from the University of California publishing in the Journal of Alzheimer’s Disease, as they have identified the specific intracellular mechanism regulated by vitamin D3 that may help the body clear the brain of amyloid beta.

There has been scant evidence in the past to show that vitamin D and the curry-derived compound, curcumin help to prevent Alzheimer’s dementia. Researchers now provide solid research-based science to explain the precise pathway used by these two natural substances to help stimulate the immune system to activate key genes involved in clearing the amyloid-beta protein.

Vitamin D3 and Curcumin Works Together to Clear Deadly Brain Plaques

Chief study author, Dr. Milan Fiala noted “This new study helped clarify the key mechanisms involved, which will help us better understand the usefulness of vitamin D3 and curcumin as possible therapies for Alzheimer's disease.” Prior research has suggested a synergistic effect between the two compounds and clearance of deadly protein tangles, but no action pathway has ever been postulated until now.

To test their hypothesis, scientists took blood samples from a group of currently diagnosed Alzheimer’s disease patients and a control group of healthy volunteers. They then isolated the immune-stimulating component of the white blood cells called macrophages. These special cells are known to target and eliminate amyloid fibrils and other waste products that accumulate in the brain before they manifest into detectable disease conditions.

Researchers then incubated some of the extracted immune cells for a 24 hour period in a solution containing the active form of vitamin D3 (1a, 25-dihydroxyvitamin D3). Other cells were exposed to a standardized curcumin extract. Past studies have shown that there are two types of macrophages, Type I and Type II that independently perform different functions, yet must work together to effectively remove amyloid protein in the brain.

Supplement with Vitamin D Daily to Attain Optimal Blood Saturation Levels

The scientists found that Type I macrophage activity is greatly enhanced with optimal saturation of vitamin D3, and Type II immune cells are supported by the presence of curcumin. Researchers found that the action of both Type I and II macrophages are greatly enhanced by the synergistic application of vitamin D3 and curcumin together. Dr. Fiala concluded “Our findings demonstrate that active forms of vitamin D3 (and curcumin) may be an important regulator of immune activities of macrophages in helping to clear amyloid plaques.”

Proof positive now exists to support maintaining optimal blood saturation levels (50 to 70 ng/mL) of vitamin D as measured using the simple and inexpensive 25(OH)D test. Most people will need to supplement with 5,000 to 7,000 IU of vitamin D3 per day or rely on sun exposure to obtain ideal levels. Adding curcumin to your regular diet using natural curry-enriched foods or supplementing (300 to 500 mg per day standardized to 95% total curcuminoids) will provide a synergistic effect shown to help clear brain tangles and prevent Alzheimer’s dementia.

Vitamin D Hailed in the Fight against Heart Disease, Alzheimer’s Disease and Diabetes

Scientific research bodies extolling the amazing virtues of the prohormone, vitamin D have been published in rapid succession to explain the preventive mechanism shown to prevent cardiovascular disease, diabetes and Alzheimer’s disease. Three independent reviews demonstrate that maintaining a vitamin D blood level between 50 and 70 ng/mL can provide optimal protection against many chronic diseases.

Researchers’ publishing in the journal Nutrition, Metabolism & Cardiovascular Diseases provide evidence that vitamin D is intrinsically involved in the homeostasis of the cardiovascular system. Disruption of the body’s natural stasis system contributes to diabetes, obesity, elevated blood lipids, high blood pressure, endothelial dysfunction, stroke and risk of coronary artery disease. Scientists advise supplementation of 4,000 to 8,000 IU of vitamin D per day to achieve optimal levels, far above the anemic 400 IU currently recommended.

Vitamin D Controls Genetic Receptors to Guard against Chronic Disease

Scientists at the University of Miami’s School of Medicine demonstrate a direct genetic link between low vitamin D levels and the development of amyloid proteins in the brain, commonly associated with Alzheimer’s disease. Reporting in the journal Neurobiology of Aging, researchers looked at gene signaling in relation to the vitamin D receptor in 492 late onset Alzheimer’s patients and 496 control subjects.

When vitamin D receptors were not activated on the surface of individual cells due to poor vitamin D saturation in the blood, precise gene signaling went awry that halted normal clearance of the dementia-related protein clumps. The team conducting the study concluded “Our findings are consistent with epidemiology studies suggesting that vitamin D insufficiency increases the risk of developing Alzheimer’s disease.”

Test Vitamin D Blood Levels Regularly to Ensure Optimal Range

Researchers in Spain evaluated the vitamin D status of 1,226 individuals in 1996. The participants were again tested eight years later, and vitamin D levels were contrasted with development of diabetes over the course of the study. The results, published in the journal Clinical Nutrition, found that those with vitamin D blood levels above 18.5 ng/mL had an 83 percent lower risk of developing type 2 diabetes during the eight year period. No one in the study with a vitamin D score over 30 ng/mL developed type 2 diabetes.

It has become very clear from countless research studies published over the past decade that vitamin D qualifies among the most crucial and essential hormone-based nutrients. And still millions of people continue to place themselves at unnecessary risk by ignoring this information.

Most people above the age of twenty-one should supplement with a minimum of 2,000 IU of vitamin D every day and have their blood tested to ensure they reach the optimal range of 50 to 70 ng/mL. Extensive research provides more than sufficient evidence that maintaining a proper vitamin D level can dramatically lower the risk of heart disease, Alzheimer’s disease diabetes and many other chronic illnesses.

A Sound Sleep Helps Defend against Memory Loss and Alzheimer’s Disease

Alzheimer’s disease presently ranks as the sixth leading cause of death in the US, as the number of new cases is projected to triple by the year 2050 and affect as many of sixteen million people. The result of a new study presented at the American Academy of Neurology's 64th Annual Meeting has found that the level and duration of quality sleep may later affect memory function and the risk of Alzheimer's disease in later life.

Researchers determined that poor quality sleep is associated with the build-up of neural tangles between synapses that is associated with the loss of ability to form new memories and progression of Alzheimer’s dementia. Making time for seven to nine hours of uninterrupted sleep each night may be a crucial factor to Alzheimer’s risk reduction as we age.

A Good Night’s Sleep Dramatically Lowers Risk of Developing Brain Plaques and Alzheimer’s Disease

The lead study author, Dr. Yo-El Ju from the Washington University School of Medicine in St. Louis noted “Disrupted sleep appears to be associated with the build-up of amyloid plaques, a hallmark marker of Alzheimer’s disease, in the brains of people without memory problems”. In an effort to determine the link between poor sleep habits and cognitive decline, researchers tested the sleep patterns of 100 people between the ages of 45 and 80 who were free of dementia.

Half of the participants tested had a family history of Alzheimer’s disease, while a second control group had no familial history of the disease. A special device used to measure sleep patterns was placed on all participants for a period of two weeks to assess quality and depth of sleep time. Additionally, sleep diaries and questionnaires were employed to further analyze sleep cycles.

Eight Hours of Sleep Necessary for Optimal Brain Function and Health

The study found that 25% of the subjects tested showed signs of amyloid plaques, a consistent marker of Alzheimer’s disease progression. Although the participant’s averaged 8 hours of sleep each night, this was reduced to 6.5 hours due to sleep disruptions during the night that affected the total sleep time and quality of deep sleep required by the brain to perform repair functions.

Those who did not wake up frequently during the night were 5 times less likely to possess the amyloid plaque build-up compared to those who slept poorly or less than 7 total hours. Participants who did not sleep well were significantly more likely to exhibit the amyloid markers associated with cognitive decline resulting in Alzheimer’s disease.

Although this study did not provide a direct reason for the finding, scientists believe that the amyloid protein clumps and tangles that occur as a normal process of metabolism in the brain are only cleared during quality sleep time and duration of 7 to 9 hours each night. In addition to the myriad of lifestyle and dietary patterns presently known to help prevent most chronic diseases such as Alzheimer’s, a good night’s sleep in a totally dark room with no interruptions should now be added to the top of the risk reduction list.

Curcumin Protects against Prostate Cancer and Alzheimer’s Dementia

Curcumin, the active anti-inflammatory compound found in the Indian spice tumeric, has gained an impressive reputation in the fight against many deadly forms of cancer. New evidence released in the journal Cancer Research finds that the natural phenol can slow prostate tumor growth by blocking receptors used to propagate cell tissue growth.

Additional research published in the journal PLoS One explains the precise mechanism exerted by curcumin molecules to target the amyloid fibrils associated with the unnatural progression of protein-like plaque tangles that are characteristic in Alzheimer’s disease patients. Adding curry spice to your healthy diet or supplementing daily with a standardized curcumin capsule will help win your individual war against cancerous proliferation and Alzheimer’s dementia.

Curcumin Blocks Prostate Cell Receptors to Thwart Cancer Progression

Prostate cancer is one of the most common forms of the disease, with more than 250,000 diagnoses in the US each year. Any natural compound that targets the proliferation of prostate cancer cells would provide a significant remedy compared with the allopathic methods of radiation, surgery and chemical agents. To conduct the study, researchers subjected prostate cancer cells to hormone deprivation in the presence and absence of curcumin with ‘physiologically attainable’ doses.

The researchers found that curcumin blocked two genetic receptors necessary for prostate cancer advancement. These receptors have been shown is past studies to predict cancer incidence and rate of growth of existing tumors. They noted that the spice extract was “a potent inhibitor of both cell cycle and survival in prostate cancer cells.”

Curcumin Enhances Brain Activity to Improve Cognition and Shield against Alzheimer’s Disease

The lead study author, Dr. Karen Knudsen and her team found that other cancer cell lines multiply by a similar receptor mechanism and may also be inhibited by the curry compound. She commented that curcumin “also has implications beyond prostate cancer… in other malignancies, like breast cancer. In tumors where these play an important function, curcumin may prove to be a promising therapeutic agent.”

In a separate research body, scientists found that curcumin prolongs life and enhances activity of brain neurons, acting as a neuroprotective shield against Alzheimer’s disease advancement. The research team determined that curcumin acted to prevent the damaging accumulation of amyloid fibrils around the nerve synapse. Amyloid tangles are known to prevent normal electrical and chemical transmissions required to form memories and maintain cognition.

Scientific research models continue to extol the virtues of natural spice and herbal extracts such as curcumin to help prevent and treat many deadly diseases that kill countless millions each year. Incorporate curry spices as part of your healthy diet or include a daily supplement (250 mg to 500 mg standardized curcumin extract) to significantly lower cancer risk and support healthy brain function.

Regular Fish Consumption Lowers Alzheimer’s Disease Risk

Researchers from the University of Pittsburgh found that people who eat baked or broiled fish on a weekly basis may be improving their brain health and lowering their risk of developing Mild Cognitive Impairment (MCI) and Alzheimer’s disease. The results, released at the annual meeting of the Radiological Society of North America established a direct relationship between fish consumption, brain structure and Alzheimer's risk.

The study determined that eating baked or broiled fish once per week led to better preservation of gray matter volume on MRI scans in brain areas at risk for Alzheimer's disease. Health-minded people may be able to dramatically lower the risk of developing this most feared memory-robbing illness.

Regular Fish Consumption Preserves Brain Volume and Cognitive Function

Dr. Cyrus Raji, M.D., Ph.D., from the University of Pittsburgh Medical Center and the University of Pittsburgh School of Medicine and his team developed a cohort of 260 cognitively normal individuals. Information on fish consumption was gathered using the National Cancer Institute Food Frequency Questionnaire. 163 participants consumed fish on a weekly basis, and the majority ate fish one to four times per week.

Each subject was examined using a 3-D volumetric MRI scan of the brain to measure gray matter volume. The test was used to model the relationship between weekly fish consumption at baseline and brain structure after a period of ten years. Data was then analyzed to determine if gray matter volume preservation associated with fish consumption reduced the risk for Alzheimer's disease. The study controlled for age, gender, education, race, obesity, physical activity, and the presence or absence of apolipoprotein E4 (ApoE4), a gene that increases the risk of developing Alzheimer's.

Eating Fatty Fish Once Per Week Preserves Cognitive Function

The findings showed that consumption of baked or broiled fish on a weekly basis was positively associated with gray matter volumes in several areas of the brain. Higher grey matter brain volume correlates with increased cognitive function and is commonly used to determine progression of degenerative conditions such as Alzheimer’s. Maintaining grey matter volume over a five-year period lowers risk of Alzheimer’s disease by five-fold.

Dr. Raji concluded “Consuming baked or broiled fish promotes stronger neurons in the brain's gray matter by making them larger and healthier… this simple lifestyle choice increases the brain's resistance to Alzheimer's disease and lowers risk for the disorder.” Eating fatty fish at least once per week (preferably at several meals) improves working memory and allows people to focus on tasks that commit information to short-term memory, improving cognitive function and lowering the risk from Alzheimer’s disease.

Lower Body Weight as we Age Linked to Increased Alzheimer’s Disease Risk

Many lifestyle factors are associated with the development of the memory-robbing form of dementia known as Alzheimer’s disease. Smoking, diet, lack of exercise and poor B-vitamin status all contribute to the sixth most prevalent cause of death each year in the US. Past studies have shown that excess weight in mid-life increases the risk of developing Alzheimer’s disease.

Evidence published in the journal Neurology finds that low body weight (as measured by Body Mass Index or BMI) is a strong predictor for those at risk of developing this most devastating form of dementia. Proper weight management at all stages of life is critical to lower the risk for developing Alzheimer’s disease.

Underweight during Advancing Years Associated with Increased Alzheimer’s Disease Risk

Natural health followers have long known that excess abdominal fat and obesity are critical factors that promote an unhealthy cascade of metabolic reactions that lead to cognitive decline and eventually, Alzheimer’s disease. The result of a new study explains the delicate relationship between body weight and dementia risk, as advancing years and a lower BMI are show to significantly increase risk for future development and progression of the disease.

Researchers examined 506 people with advanced brain imaging techniques and analyses of cerebrospinal fluid (CSF) to look for biomarkers associated with Alzheimer's disease. Many biochemical markers are known to be present years before the first symptoms begin. The group was comprised of people with no memory problems, people with mild cognitive impairment, or mild memory problems, and people with a diagnosis of Alzheimer's disease.

Study Finds Direct Link between Low BMI and Amyloid Brain Plaque Formation

After testing body weight and reviewing the results of CSF and brain imaging tests, scientists found that in people with no memory or thinking problems and in people with mild cognitive impairment, those who had the Alzheimer's biomarkers were also more likely to have a lower BMI than those who did not have the biomarkers. Dr. Jeffrey Burns, the study leader noted, “85 percent of the people with mild cognitive impairment who had a BMI below 25 had signs of the beta-amyloid plaques in their brains that are a hallmark of the disease, compared to 48 percent of those with mild cognitive impairment who were overweight.” 

Researchers conducting the study determined that low body weight and advanced age may result in damage to an area of the brain called the hypothalamus that plays a role in regulating energy metabolism and food intake. Dr. Burns concluded “These results suggest Alzheimer's disease brain changes are associated with systemic metabolic changes in the very earliest phases of the disease.” The information provided by this study underscore the importance of maintain a healthy body weight (for most people measured with a BMI range of 20 to 25) throughout life and advancing years to lower the risk of developing Alzheimer’s disease.

B Vitamins and Omega-3 Fats Slow Alzheimer’s Disease Progression

Proper nutritional status attained by consuming a healthy diet teaming with natural vitamins and minerals along with optimization of omega fat lipid ratios can help to prevent cognitive decline associated with Alzheimer’s disease (AD) pathology. Researchers studying the effects of nutrition at Oxford University in England found that daily supplementation with folic acid and vitamins B6 and B12 lowered levels of homocysteine, a known risk factor leading to decline in cognition and memory.

Further evidence published in the journal Molecular Nutrition & Food Research explains that a disproportionate ratio of omega-6 to omega-3 fatty acids plays a crucial role in the development of AD in later life. Cellular nutritional saturation from diet and appropriate supplementation with B vitamins and omega-3 fats may provide the cornerstone to prevent this most feared memory-robbing disease.

B Vitamin Supplementation Shown to Lower Homocysteine by 30% and Slow Brain Atrophy

Reporting in the International Journal of Geriatric Psychiatry, scientists examined the proposed link between elevated homocysteine levels and cognitive decline. Homocysteine has already been shown to dramatically increase the risk of heart disease and heart attack in prior studies. Researchers examined 266 people over the age of 70 with established mild cognitive impairment, and broke them into two groups. One group was supplemented with folic acid, vitamin B6 and B12, vitamin cofactors that lower homocysteine levels, while the second group received a placebo.

Brain wasting or atrophy is a common sign of cognitive impairment and is closely associated with Alzheimer’s dementia. The rate of brain atrophy is increased by higher concentrations of homocysteine in the blood and brain tissue. Researchers examining the results of this study found that the group supplemented with B vitamins for a period of two years experienced a 30% reduction in homocysteine levels. They found dramatic improvements in mental tests including global cognition and episodic memory (69% improvement in word recall memory) compared to the control group.

Omega-6 to Omega-3 Fat Ratio in Diet Creates an Imbalance in the Brain

The standard American diet (SAD) includes large quantities of oxidized omega-6 fats from fried and processed foods when compared to omega-3 fat consumption (from fish, nuts and seeds). The ratio of omega-6 to omega-3 fatty acids ranges from 20:1 to as high as 50:1 (ideal range is no more than 4:1), creating a perpetual degree of inflammation throughout the body. Researchers have determined that this imbalance creates a disturbance in brain chemistry affecting neurotransmitter balance and electrical firing in the brain that sets the stage for amyloid tangles and cognitive decline.

Reestablishing omega fat homeostasis by balancing toward a 1:1 intake ratio and correcting B vitamin nutritional deficiencies provide deep insight toward understanding and controlling risk factors for the development of many forms of dementia including Alzheimer’s disease. Most middle aged adults will want to include a high potency B vitamin supplement (preferably formulated from natural food sources) and include omega-3 fats from diet or fish oil consumption to lower dementia risk factors.