Zinc Fights Infection and Inflammation by Boosting the Body’s Immune Response

Infection from bacterial and viral agents can pose a significant threat to human health, as it fuels the flames of systemic inflammation known to contribute to cancer, heart disease, dementia, diabetes and stroke. Many lifestyle factors, including diet, stress and exposure to environmental and household toxins contribute to elevated levels of inflammation throughout the body that never subside, creating a cellular environment that is favorable to disease propagation. Fortunately there are a number of natural compounds and nutrients that help combat inflammation and lower risk of infection and chronic disease.

Zinc Activates the Innate Immune Response to Help Fight Viral and Bacterial Pathogens

A research team from Ohio State University has released the result of a study revealing how zinc helps control infections by gently tapping the brakes on the immune response in a way that prevents out of control inflammation that can be damaging and even deadly. Working with human cell cultures, the scientists have demonstrated how a specific protein ushers zinc into key cells that stimulate a critical immune response to fight against infection. The mineral interacts with a cellular process that neutralizes infection and helps balance the normal immune response.

Scientists present groundbreaking work that demonstrates for the first time how zinc disables an important pathway to effectively ensure that the immune response does not spiral out of control in response to an infection, and similarly to perpetually elevated levels of inflammation referred to as systemic. Senior study author, Dr. Daren Knoell commented “Without zinc on board to begin with, it could increase vulnerability to infection… our work is focused on what happens once you get an infection… if you are deficient in zinc you are at a disadvantage because your defense system is amplified, and inappropriately so.”

Include Dietary Sources of Zinc and Supplement as Necessary to Improve Immune Defenses

Monocytes, which are white blood cells that provide the first line of defense against an invading pathogen, were extracted from human blood samples to determine what happens when the immune response is launched. Researchers found that when a pathogen is detected, a series of complex responses occur to wake the innate immune response utilizing the nuclear-factor kappa beta pathway (NF-kB). The team showed that once NF-kB is activated, a gene is expressed that allows zinc to be ushered from the bloodstream into the cell where it can bind with proteins that block the activity of the pathogen and halt excess inflammation.

Dr. Knoell concluded “We believe that our findings help to narrow an important gap that has existed in our understanding of how this relatively simple metal helps us defend ourselves from infection.” Zinc deficiency affects two billion people around the world, representing an estimated forty percent of the elderly in the US, and helps to explain why our aging population is unable to fight the most common infections. Dietary sources of zinc include beans, nuts, some shellfish, whole grains, fortified cereals and dairy products. Health-minded individuals may want to avoid meat, dairy and grain sources and supplement with 15 to 25 mg per day to fight infection and systemic inflammation.

Zinc is Essential to Improve Brain Communications and Improve Memory

Zinc is an essential mineral known to improve skin tone, aid wound healing, fight cancer and shorten the length of the common cold. Researchers publishing in the journal Neuron now identify the crucial role this super-nutrient plays in support of memory formation and cognitive stability. Additionally, they have found that zinc may also play a part in controlling the devastating occurrence of epileptic seizures.

For the first time, scientists have been able to watch zinc in action as the nutrient regulates communications between neurons and the hippocampus to improve memory and learning capabilities. Ensuring proper intake of zinc is an important step toward optimal brain function and may prevent cognitive decline as we age.

Zinc Improves Communication between Neurons to Improve Cognition

Researchers at Duke University Medical Center and chemists at the Massachusetts Institute of Technology collaborated to study the effects of zinc on brain function. Scientists experimenting with mice used a chemical that binds with zinc to eliminate it from the brain of the test animals. They found that in the absence of the mineral, communications between neurons was significantly diminished and that zinc is vital for controlling the efficiency between nerve cells in the hippocampus.

For more than a half century, scientists have understood that high concentrations of zinc are deposited within nerve cells, called vesicles that package the transmitters which enable nerve cells to communicate. The highest concentrations of brain zinc are found among the neurons of the hippocampus that control the high functions of learning and memory.

Researchers Find Zinc Levels in the Brain Control Memory and Learning Functions

By artificially regulating the level of zinc in the brain of the test animals, researchers were able to confirm that eliminating zinc from the neural vesicles also prevented enhanced communication. By increasing levels of the mineral, they were able to significantly restore enhanced communications in the hippocampal region to improve learning and memory capabilities.

The results of this study conducted using mice can be extrapolated to humans because zinc is known to play a similar role in the brain of both species. Zinc deficiency in the typical western diet is rapidly becoming a serious problem that threatens human health. Due to poor farming practices and the abundance of nutrient-deprived processed foods, many children and adults suffer from a chronic insufficiency of the mineral.

Over time, lack of zinc from dietary sources can result in immune system depression, decline in sexual health and increased risk of dementia and cognitive decline. Ideal dietary sources of zinc include liver, beef and lamb. Vegetarians can include nuts, seeds and peas to obtain the micronutrient. Alternatively, zinc supplements are available (30 to 50 mg per day) to help maintain healthy systemic levels that improve memory, learning and cognition.