Active Compounds in Green Tea and Red Wine Halt Alzheimer’s Disease Progression

Alzheimer’s disease is characterized by an unnatural accumulation of amyloid plaque aggregates around nerve synapses that block the transmission of electrical and chemical transmitters that allow the brain to retain a high level of cognitive function and to store and retain memories. Millions of middle aged and older Americans suffer from some stage of Alzheimer’s disease, as the illness continues to escalate at an epidemic rate. It is projected that the prevalence will nearly quadruple in the next 50 years, by which time approximately 1 in 45 Americans will be afflicted with the disease.

Green Tea and Red Wine Extracts Impede Amyloid Formation to Prevent Alzheimer’s Development

The past decade has uncovered a small handful of natural, bioactive compounds that easily cross the blood-brain barrier where they have been found to alter the progression of Alzheimer’s disease. Researchers from the University of Leeds in the UK have determined that natural chemicals found in green tea and red wine may disrupt a key step of the Alzheimer's disease pathway. Publishing in the Journal of Biological Chemistry, scientists have identified the process which allows harmful clumps of protein to latch on to brain cells, causing them to die.

Scientists understand that amyloid proteins in the brain clump together to form toxic, sticky balls of varying shapes. These amyloid balls latch on to the surface of nerve cells in the brain by attaching to proteins on the cell surface called prions, ultimately causing nerve cells to malfunction and die. Study co-author Dr. Jo Rushworth commented "We wanted to investigate whether the precise shape of the amyloid balls is essential for them to attach to the prion receptors, like the way a baseball fits snugly into its glove.”

Supplement Daily with EGCG and Resveratrol to Slow Disease Progression

The team wanted to determine if it was possible to prevent the amyloid balls from binding to prions by manipulating their shape and stop the cells from dying. Scientists formed amyloid balls in a test tube and then added them to human and animal brain cells. Study authors concluded "When we added the extracts from red wine and green tea, which recent research has shown to re-shape amyloid proteins, the amyloid balls no longer harmed the nerve cells.”

Researchers determined that the bioactive compounds in green tea and red wine (EGCG and resveratrol) distorted the shape of the amyloid balls, preventing them from binding with prions and disrupting cellular function. Complimentary studies have also determined that curcumin, the active compound in the curry spice turmeric, crossed the delicate blood-brain barrier to halt the advancement of dementia. Health-minded individuals should consume green tea and red wine or take standardized supplements regularly to help prevent the initial development and progression of Alzheimer’s disease.

Curcumin Prevents Brain Degenerative Diseases Including Parkinson’s and Alzheimer’s

Curcumin, the bioactive compound found in the Indian curry spice turmeric and commonly referred to as ‘holy powder’, has been used for centuries in folk medicine to treat wounds, infections, and other health problems. Today researchers are using the power of the evolving science of epigenetics to reveal how curcumin is crucial in the fight against many forms of cancer, as it causes metastatic cells to undergo programmed cell death, or apoptosis.

Researchers from Michigan State University, publishing the result of a study in the Journal of Biological Chemistry have found that this amazing natural compound is able to prevent the destructive formation of alpha-synuclein proteins that are the hallmark presentation in many neurodegenerative disease such as Parkinson’s and Alzheimer’s disease. Curcumin is one a very select group of structures that is able to cross the delicate blood-brain barrier to affect biochemical and electrical activities in the brain. The turmeric derivative has demonstrated the unique capability to prevent clumping or aggregation leading to disease development.

Curcumin Aids Protein Folding to Prevent Brain Tangles and Degeneration

The team lead researcher, Dr. Basir Ahmad and scientists conducting the study commented “Our research shows that curcumin can rescue proteins from aggregation, the first steps of many debilitating diseases… more specifically, curcumin binds strongly to alpha-synuclein and prevents aggregation at body temperatures.”

The team used precise lasers to study the split-second formation of proteins known as ‘protein folding’. Normally, proteins are folded at lightning fast speed at the direction of genes and DNA sequences. Damage to DNA caused by poor diet and lifestyle factors from epigenetic alterations results in mis-folded proteins and neurodegenerative disease.

Supplement with Curcumin Daily to Prevent Protein Clumping and Lower Disease Risk

Researchers found that when curcumin attaches to alpha-synuclein it not only stops clumping, but it also raises the protein’s folding or reconfiguration rate. By slowing the speed that the proteins form, curcumin effectively inhibits abnormal protein clumping to prevent tangles and damage to the nerve synapses. Chemical and electrical communications are retained that help to help prevent the early manifestation of Parkinson’s disease.

Curcumin can be added to the diet with liberal use of the Indian curry spice in meal preparation. Many people do not enjoy the taste of curry infused foods. For those individuals, nutrition advisors recommend a standardized supplement (std. to 95% total curcuminoids for maximum bioavailability) providing 300 to 500 mg daily to prevent neurodegenerative decline.

Vitamin D and Curcumin Synergistically Clear Brain Tangles to Prevent Alzheimer’s Dementia

New diagnosis of Alzheimer’s disease cases continue to mount at an unprecedented rate, threatening both the lives of those suffering from this dreaded illness and the health care system itself, as billions are spent to care for the millions suffering from this lifestyle-mediated disease. New hope is now offered by scientists from the University of California publishing in the Journal of Alzheimer’s Disease, as they have identified the specific intracellular mechanism regulated by vitamin D3 that may help the body clear the brain of amyloid beta.

There has been scant evidence in the past to show that vitamin D and the curry-derived compound, curcumin help to prevent Alzheimer’s dementia. Researchers now provide solid research-based science to explain the precise pathway used by these two natural substances to help stimulate the immune system to activate key genes involved in clearing the amyloid-beta protein.

Vitamin D3 and Curcumin Works Together to Clear Deadly Brain Plaques

Chief study author, Dr. Milan Fiala noted “This new study helped clarify the key mechanisms involved, which will help us better understand the usefulness of vitamin D3 and curcumin as possible therapies for Alzheimer's disease.” Prior research has suggested a synergistic effect between the two compounds and clearance of deadly protein tangles, but no action pathway has ever been postulated until now.

To test their hypothesis, scientists took blood samples from a group of currently diagnosed Alzheimer’s disease patients and a control group of healthy volunteers. They then isolated the immune-stimulating component of the white blood cells called macrophages. These special cells are known to target and eliminate amyloid fibrils and other waste products that accumulate in the brain before they manifest into detectable disease conditions.

Researchers then incubated some of the extracted immune cells for a 24 hour period in a solution containing the active form of vitamin D3 (1a, 25-dihydroxyvitamin D3). Other cells were exposed to a standardized curcumin extract. Past studies have shown that there are two types of macrophages, Type I and Type II that independently perform different functions, yet must work together to effectively remove amyloid protein in the brain.

Supplement with Vitamin D Daily to Attain Optimal Blood Saturation Levels

The scientists found that Type I macrophage activity is greatly enhanced with optimal saturation of vitamin D3, and Type II immune cells are supported by the presence of curcumin. Researchers found that the action of both Type I and II macrophages are greatly enhanced by the synergistic application of vitamin D3 and curcumin together. Dr. Fiala concluded “Our findings demonstrate that active forms of vitamin D3 (and curcumin) may be an important regulator of immune activities of macrophages in helping to clear amyloid plaques.”

Proof positive now exists to support maintaining optimal blood saturation levels (50 to 70 ng/mL) of vitamin D as measured using the simple and inexpensive 25(OH)D test. Most people will need to supplement with 5,000 to 7,000 IU of vitamin D3 per day or rely on sun exposure to obtain ideal levels. Adding curcumin to your regular diet using natural curry-enriched foods or supplementing (300 to 500 mg per day standardized to 95% total curcuminoids) will provide a synergistic effect shown to help clear brain tangles and prevent Alzheimer’s dementia.

Curcumin Protects against Prostate Cancer and Alzheimer’s Dementia

Curcumin, the active anti-inflammatory compound found in the Indian spice tumeric, has gained an impressive reputation in the fight against many deadly forms of cancer. New evidence released in the journal Cancer Research finds that the natural phenol can slow prostate tumor growth by blocking receptors used to propagate cell tissue growth.

Additional research published in the journal PLoS One explains the precise mechanism exerted by curcumin molecules to target the amyloid fibrils associated with the unnatural progression of protein-like plaque tangles that are characteristic in Alzheimer’s disease patients. Adding curry spice to your healthy diet or supplementing daily with a standardized curcumin capsule will help win your individual war against cancerous proliferation and Alzheimer’s dementia.

Curcumin Blocks Prostate Cell Receptors to Thwart Cancer Progression

Prostate cancer is one of the most common forms of the disease, with more than 250,000 diagnoses in the US each year. Any natural compound that targets the proliferation of prostate cancer cells would provide a significant remedy compared with the allopathic methods of radiation, surgery and chemical agents. To conduct the study, researchers subjected prostate cancer cells to hormone deprivation in the presence and absence of curcumin with ‘physiologically attainable’ doses.

The researchers found that curcumin blocked two genetic receptors necessary for prostate cancer advancement. These receptors have been shown is past studies to predict cancer incidence and rate of growth of existing tumors. They noted that the spice extract was “a potent inhibitor of both cell cycle and survival in prostate cancer cells.”

Curcumin Enhances Brain Activity to Improve Cognition and Shield against Alzheimer’s Disease

The lead study author, Dr. Karen Knudsen and her team found that other cancer cell lines multiply by a similar receptor mechanism and may also be inhibited by the curry compound. She commented that curcumin “also has implications beyond prostate cancer… in other malignancies, like breast cancer. In tumors where these play an important function, curcumin may prove to be a promising therapeutic agent.”

In a separate research body, scientists found that curcumin prolongs life and enhances activity of brain neurons, acting as a neuroprotective shield against Alzheimer’s disease advancement. The research team determined that curcumin acted to prevent the damaging accumulation of amyloid fibrils around the nerve synapse. Amyloid tangles are known to prevent normal electrical and chemical transmissions required to form memories and maintain cognition.

Scientific research models continue to extol the virtues of natural spice and herbal extracts such as curcumin to help prevent and treat many deadly diseases that kill countless millions each year. Incorporate curry spices as part of your healthy diet or include a daily supplement (250 mg to 500 mg standardized curcumin extract) to significantly lower cancer risk and support healthy brain function.

Cinnamon and Tumeric Lower Triglycerides and Insulin Triggered by High Fat Diet

Many spices such as tumeric and cinnamon are powerful antioxidants that continue to gain acceptance as natural nutrients able to assist human health and prevent chronic disease. Researchers from Penn State publishing in The Journal of Nutrition provide strong evidence that these potent spices provide a protective shield to reduce the body`s negative responses to eating high-fat meals.

A diet filled with high-fat foods that have been fried or baked with trans fats increases oxidized LDL cholesterol levels and dangerous blood fats known as triglycerides. Tumeric and cinnamon taken before a high fat meal combine to lower triglyceride response by as much as 30%, preventing a cascade of harmful metabolic events that lead to heart disease and diabetes.

Tumeric and Cinnamon Spices Lower Triglycerides and Insulin Levels

Culinary spices have peaked interest among nutritional scientists in recent years as both turmeric and cinnamon exhibit powerful antioxidant properties that may halt dangerous metabolic imbalances prompted by poor dietary choices. To conduct the study, researchers added 14 grams of a combined turmeric-cinnamon spice blend to a 1200 calorie high-fat meal, and compared the results to a control group not receiving the spice mixture.

Blood samples were taken prior to the meal and then again at 30 minute intervals for the next three and a half hours after eating. Participants were tested again one week later, and the two groups were switched to verify the accuracy of the results. Researchers found that blood levels of insulin were reduced by 21% and triglycerides dropped 31% in response to the turmeric-cinnamon mix.

Spices are Potent Antioxidants That Lower Metabolic Damage from Poor Diet

The study authors found that the spices significantly improved two critical metabolic markers that are associated with increased risk of developing diabetes and cardiovascular disorders. They commented “Adding spices to the meal significantly increased the ferric reducing antioxidant power, such that postprandial increases following the spiced meal were 2-fold greater than after the control meal.” They also found that the two spices interact synergistically and the impact was significantly greater when both spices were administered concurrently, compared to individual results.

Most health-conscious adults can benefit from a wide array of natural spices added to and consumed with many popular foods, regardless of specific dietary approach. Penn State authors concluded “The incorporation of spices into the diet may help normalize postprandial insulin and TG (triglyceride) and enhance antioxidant defenses.”  Include turmeric and cinnamon to your favorite meals, or take a high quality supplement with meals to maximize your defense against metabolic dysfunction and heart disease.

Resveratrol and Curcumin Promote Cell Regulation to Lower Cancer Risk

Every cell in our body generates waste that must be removed to preserve normal function. This process is called autophagy and is known to decline in efficiency as we age. When excess cellular debris is allowed to accumulate in our cells, normal function is altered and the cell begins to deteriorate.

This paves the way for accelerated aging and chronic illnesses including heart disease, many cancer lines and neurologic disorders such as Alzheimer’s disease. Cutting edge research underscores the importance of natural nutrients such as resveratrol, curcumin, berries and leafy greens to induce autophagy and lower the risks associated with premature aging.

Resveratrol Triggers Natural Cellular Housekeeping

Resveratrol is a powerful nutrient that has been shown to directly influence genes that regulate metabolic mechanisms and promote longevity. In addition to mimicking the effect of calorie restriction, resveratrol is emerging as a compound that can be used to assist the removal of cellular debris and improve efficiency.

The result of a study published in the Impact Journal on Aging demonstrates how resveratrol triggers autophagy in otherwise dormant cells. Resveratrol is shown to activate a series of proteins known as SIRT 1 that protect the delicate functional structures within the cell body and stimulate waste removal. This action effectively sets off a chain of events that leads to improved cellular efficiency and anti-aging characteristics.

Curcumin is a Powerful Anti-Cancer Agent

Curcumin has a long history as an effective weapon in the fight against cancer and as an anti-aging nutrient. Derived from curry powder, curcumin has been shown to initiate normal cell death in abnormal cancer cells in a process called apoptosis. The nutrient works on cellular DNA to stimulate the removal of waste debris and can target precancerous tumor cells to undergo programmed destruction.

Information published in the British Journal of Cancer explains that curcumin targets several death pathways in cancer cells that can become disabled, allowing uncontrolled growth and proliferation. Researchers found the curry extract to be particularly effective in cancers of the digestive tract and esophagus and concluded, “it is likely that curcumin and indeed some of its bioavailability-enhanced analogues are realistic options to be considered in the future for targeted molecular cancer prevention and treatment.”

Berries and Leafy Greens Found to be Neuroprotective

Blueberries, strawberries and spinach are natural foods that exhibit a strong protective shield to the aging brain. An analysis published in The Journal of Neuroscience demonstrates the capacity of these super foods to induce autophagy. Berries and leafy greens are packed with polyphenols and anthocyanins that convey powerful antioxidant and anti-inflammatory properties to these foods.

The study authors found that compounds in berries and spinach were able to cross the blood-brain barrier and directly influence the functional capacity of neurons. The lead study author noted “the findings from this research suggest that nutritional intervention with fruits and vegetables may play an important role in reversing the deleterious effects of aging on neuronal function and behavior.” 

Cellular housekeeping is an essential task that determines our rate of aging and risk of developing chronic disease. In addition to proper diet and regular exercise, health-minded individuals can take advantage of natural nutrients such as resveratrol and curcumin and foods like berries and spinach to maximize cellular autophagy and extend our natural lifespan.

Curcumin is a Powerful Anti-Cancer Agent

(Article first published as This Indian Spice Packs a Powerful Anti-Cancer Punch on Technorati.)

Known as a staple in the Indian diet, curry and its powerful polyphenol derivative curcumin have rapidly gained attention as a potent antioxidant compound that is used to prevent and treat many forms of cancer. Curcumin is taking its rightful place among a small handful of agents that fight cancer at the genetic level by inhibiting ten critical initiation steps necessary for development and progression of the disease.

The spice can no longer be considered an herbal remedy as it has demonstrated efficacy in more than 240 peer reviewed research studies over the past year alone. Scientists continue to provide conclusive evidence that indicates all health-minded adults should include curcumin as part of their regular diet.

Curcumin Influences Gene Expression That Leads to Cancer

Cancer is known to develop through ten independent causative factors including DNA damage, chronic inflammation, cellular signaling dysfunction, abnormal cell death and metastasis. As if designed by nature to provide a protective shield against each of the factors known to promote cancer, curcumin has been shown to inhibit and halt the expression of genes that allow cancer cells to multiply.

Publishing in the AAPS Journal, researchers found that curcumin is an inexpensive natural compound that fights cancer at its root cause by derailing the initiation phase of ten different pathways used by the disease to multiply and spread throughout the body. Curcumin has also been shown to interfere with the production of advanced glycation end products that promote the accumulation of dangerous inflammatory byproducts that lead to cancerous mutations.

Curcumin Shown to Trigger Natural Cell Death to Prevent Cancer

The FEBS Journal reports that curcumin is particularly effective in targeting hormone-dependent forms of the disease such as breast cancer. The study found that curcumin is able to induce apoptosis (normal programmed cell death) in the most resistant breast cancer cells that lack estrogen receptors. The spice targets only cancerous cells causing them to self-destruct by destroying the mitochondria that power the rapidly growing tumor tissue.

Curcumin is a potent agent in the fight against colon cancer, an insidious form of the disease that ranks second among cancer deaths taking the lives of more than 50,000 Americans each year. The Journal of Interferon and Cytokine Research provides evidence that curcumin slows the progression from colon polyp to cancerous growth by damping the pro-inflammatory cytokine called NF-kB. This action halts the development of cancer cells before they can become detectable tumors.

An extensive library of research underscores the importance of curcumin as an anti-cancer agent. As the second leading cause of death, cancer will affect 1 in 3 women and half of all men during their lifetime. Any natural compound that can help to lower these statistics should be embraced by traditional and alternative medical institutions alike. Nutritionists recommend supplementing with 250 to 400 mg of curcumin twice daily with meals to provide optimal cancer protection.

Curcumin, Garlic and Green Tea Lower Risk of Chronic Disease

(Article first published as Powerful Nutrient Trio Protects the Brain and Heart on Technorati.)

Humans have relied on natural extracts and powerful nutrients to prevent disease and maintain health for countless generations. The typical diet consists mostly of foods that have been heavily processed so that most of the vitamins and minerals we need to sustain optimal health have been eliminated. 

Estimates are that only 1 in 20 people consumes the minimum daily recommendation of 5 servings of vegetables and fruits. Most individuals are therefore deficient in a wide array of phytonutrients supplied by fresh produce that are essential for disease prevention. You can improve your health by adding these natural nutrients to your diet or supplemental arsenal.

Curcumin Shown to Protect the Brain and Liver

Curcumin is the active component of the Indian spice, tumeric that gives curry its deep yellow color. This potent antiviral is known to provide critical protection to the brain as it can easily cross the blood-brain barrier. Researchers have shown that the spice extract can effectively inhibit the formation of brain plaque that is associated with Alzheimer`s disease and other neurological disorders such as Parkinson's.

New research published in the journal Endocrinology confirms how curcumin can help prevent the accumulation of fat in the liver. Fatty liver disease is a potentially fatal affliction that worsens with excess body weight and obesity. The liver is our primary organ responsible for filtering toxins from the blood as well as hundreds of other important metabolic functions within our body. Any natural nutrient that can help keep fat from clogging the normal activity of our liver is critical to our health.

Garlic Dramatically Lowers Risk from Many Cancer Lines

Sulfur is the active compound that makes garlic difficult for many to eat raw and also contributes to its long list of health benefits. Our body uses the breakdown of sulfur to power a process known as methylation. Through this chain of chemical reactions our body is able to perform many critical functions that promote healthy immune response and clear waste products from our cells.

The result of a study published in the American Journal of Clinical Nutrition demonstrates that a diet including garlic (and onions) was inversely related to the risk of many forms of cancer. Pancreatic cancer risk was lowered by 54%, prostate cancer by 51% and colon cancer rates were cut in half. Researchers believe that an improved immune response is behind the cancer fighting ability associated with garlic.

Green Tea in the Fight Against Obesity and Heart Disease

The catechins in green tea (EGCG) have been known for their ability to fight diseases ranging from cancer to dementia and heart disease. Extensive research has shown that EGCG can effectively inhibit the blood supply required for the development and proliferation of cancer cells. Risk for developing deadly lung cancer was reduced by 66% in participants taking a concentrated form of green tea extract.

Green tea is also a powerful tool in the fight against heart disease. Information published in the Journal of the American College of Nutrition explains how EGCG increases the oxidation of fat by boosting metabolism. This action assists in weight loss by increasing base metabolic rate. Green tea also lowers the risk of coronary artery disease by limiting oxidized LDL cholesterol that causes arterial plaque.

Natural antiviral nutrients are vital to our health. Those interested in lowering their risk of cancer, heart disease, dementia and liver dysfunction should be certain to include these powerful compounds through diet or supplementation.

Carnitine and Curcumin Slow Brain Aging and Improve Memory

(Article first published as Super Nutrients Shown to Reverse Brain Aging and Cognition on Technorati.)

Cognitive decline and memory loss are considered a normal function of aging by millions of people. A `senior moment` is the term coined to describe momentary forgetfulness that some people experience from time to time. Lapses in memory are not normal and are a strong indicator of brain decline that typically progresses over a period of several decades. 

Our brain requires nutrition, healthy blood flow and oxygen just as any organ to remain `plastic` and be able to function at optimal capacity. Years of dietary abuse and exposure to toxic household and environmental chemicals cause brain stress, inflammation and insulin resistance. A trio of super nutrients demonstrates the capacity to improve brain health and lower the risk of cognitive decline.

 

Memory Decline is Not a Normal Part of Aging

The brain receives 20% of your body`s supply of freshly oxygenated blood. When this supply is restricted through narrowing of the arteries and inflammation, the brain experiences stress and cognition is diminished. Any nutrient that can specifically target and increase the flow of blood and oxygen to the brain can slow or even reverse brain decline and restore memory and learning abilities.

Carnitine Promotes Brain Rejuvenation

Carnitine is a naturally occurring amino acid that has been shown to benefit brain health, improve stress tolerance and protects against excitotoxic damage to brain neurons. Carnitine helps to prevent the nerve-related wear and tear that promotes the buildup of amyloid plaque and is associated with Alzheimer`s disease. Information released in the European Journal of Pharmacology demonstrates that the amino acid inhibits the secretion of nerve cell proteins that become tangled plaque in the brain.

Curcumin Reduces Brain Mediated Stress

The normal process of metabolic function creates free radicals that are damaging to the brain. We can limit the effects of free radicals by eating a naturally raw diet filled with fresh vegetables, nuts and seeds and limiting stressful situations. Super nutrients such as curcumin can help keep free radicals at bay by absorbing the impact of these damaging particles. The results of information published in the journal Neurotoxicity show that curcumin deactivates one of the most damaging free radicals known as peroxynitrite by boosting antioxidant defenses in the brain and lowering inflammatory responses.

DHA Required for Optimal Brain Function

The Omega-3 fat DHA continues to gain importance for its ability to rejuvenate brain cells and prevent cognitive decline. Not only is this essential fat required for neuronal and synaptic connections, but research also confirms that it actually controls the genetics that power the development of neural stem cells. Research published in the journal Neuroscience details how DHA helps to maintain brain plasticity and can prevent the decline that often leads to vascular dementia and Alzheimer`s disease.

Too many people take brain health for granted and accept a steady decline in memory and learning to be normal and acceptable. While the brain remains well protected, it`s still susceptible to many of ravages brought about by poor diet, stress and the environment. Natural nutrients including carnitine, curcumin and DHA are shown to prevent cognitive decline, improve memory and ensure vibrant brain health through advancing age.