Coenzyme Q10 Prevents and Treats Heart Disease by Attacking Multiple Metabolic Pathways

Coenzyme Q 10 (CoQ10) is well known as a critical compound required by the body to facilitate normal breakdown of adenosine triphosphate (ATP) within each cell into energy we need for metabolism and life itself. It should come as no surprise that this vital natural enzyme complex may hold the key to prevention and reversal of many potentially life-threatening forms of cardiovascular disease.

Several research studies reveal that CoQ10 works at a cellular level to protect delicate DNA and reduce dangerous inflammatory levels that are closely linked to heart disease. Further evidence exists to explain how the coenzyme improves blood flow to the heart muscle and enhances vascular elasticity to prevent arterial stiffening, commonly referred to as ‘hardening of the arteries’. Scientists have also found that CoQ10 lowers unhealthy levels of oxidized LDL cholesterol by modulating gene signals involved with cholesterol metabolism.

Coenzyme Q10 Lowers DNA Stress and Inflammation to Improve Heart Health

Researchers from Spain publishing in the journal Age found that supplementing CoQ10 while consuming a healthy Mediterranean diet lowered markers of DNA damage within cells and reduced systemic inflammation. The net effect of this human study was a dramatic reduction in biological markers associated with cardiovascular disease.

The study was conducted by placing twenty participants, aged 65 or older, on three different diets for four weeks each: a Western diet, a Mediterranean diet, or a Mediterranean diet with 200 mg of Q10. The group taking the Mediterranean diet experiences moderately lowered levels of DNA stress, largely due to the anti-inflammatory effect of a diet high in monounsaturated fats in the form of olive oil.

The group that included CoQ10 had a marked decline in all metabolic markers known to promote DNA damage and a decline in cardiovascular health. The study authors concluded that the Mediterranean diet plus CoQ10 “improves oxidative DNA damage in elderly subjects and reduces processes of cellular oxidation. Our results suggest a starting point for the prevention of oxidative processes associated with aging.”

CoQ10 Increases Arterial Elasticity by Improving Cellular Energy

A Chinese research team published in the journal Atherosclerosis examined the effect of CoQ10 on the delicate endothelial lining of the coronary arteries. Endothelial dysfunction is known to be a progenitor to heart disease and heart attack. The scientists demonstrated that individuals placed on CoQ10 (300 mg per day for 12 weeks) showed marked improvement in arterial stiffness due to increased blood flow and improved cellular energy within their endothelial cells.

Scientific evidence is mounting to support coenzyme Q10 as a powerful tool when used to improve cellular energy levels and fight the advances of cardiovascular disease. Most new research is now evolving around the reduced form of the coenzyme known as ubiquinol. Ubiquinol has been found to be up to eight times more potent than the standard CoQ10 and last much longer in blood circulation. It is quite apparent that most health-minded individuals should supplement with CoQ10 (50 to 300 mg per day depending on cardiovascular health) to improve energy levels and improve vascular circulation to the heart.

Mediterranean Diet and Calorie Restriction Promote Brain Health and Longevity

Researchers have long theorized that a Mediterranean diet full of vegetables, fruit, fish, nuts, seeds and olive oil can help promote good health. Scientists at the Sahlgrenska Academy in Sweden reporting in the European journal AGE provides the unanimous results of four independent studies that demonstrate this style of eating not only lowers the risk from many chronic and potentially fatal diseases, but actually extends healthy lifespan in aging adults.

A separate research body appearing in the Proceedings of the National Academy of Sciences (PNAS) explains that calorie restriction or consuming about twenty-five percent fewer calories each day, turns on a molecule that helps the brain stay young. Extrapolating the results of both studies suggests that following a Mediterranean diet with fewer calories may provide a valuable key to preserving memory, lowering risk of serious illness and extending a healthy life span.

Mediterranean Diet Improves Lifespan by Twenty Percent

Swedish researchers studied the effects of a Mediterranean diet on older people in the Swiss population. They developed a unique study designed to compare 70-year-olds who eat a Mediterranean diet with others who have eaten more meat and animal products. The intent was to confirm the positive results suggested by a myriad of studies over the past decade that found a diet low in animal meats and high in fresh vegetables and monounsaturated fats can improve health and extend lifespan.

The result of the study indicated that those who eat a Mediterranean diet have a 20% higher chance of living longer. The study leader, Dr. Gianluca Tognon commented “This means in practice that older people who eat a Mediterranean diet live an estimated two to three years longer than those who don't”. Three additional studies awaiting publication support these results. Dr. Tognon concluded “there is no doubt that a Mediterranean diet is linked to better health, not only for the elderly but also for youngsters.”

Calorie Restricted Diet Slows Brain Aging to Improve Cognition

An independent study found that overeating may cause brain aging while eating less turns on a molecule that helps the brain stay young. Italian researchers demonstrated that a molecule called CREB1 is triggered by a calorie restricted diet and activates many genes linked to longevity and to the proper functioning of the brain. Calorie restriction is defined as eating 25 to 30 percent less than normal while maintaining optimal nutrition.

Researchers conducting the study concluded “This discovery has important implications to develop future dietary therapies to keep our brain young and prevent brain degeneration and the aging process.” Compiling the available scientific evidence shines a critical light on how the type of food we consume (Mediterranean diet) and the quantity (Calorie Restriction with Optimal Nutrition) can help prevent premature brain aging and lower the risk of cognitive decline as we age.