Scientists Explain How Vitamin D and Omega-3 Fats Synergistically Prevent Alzheimer’s Disease

Alzheimer’s disease is characterized by a loss of short term memory, cognition and thought processes that define the personality of a person, and new cases are exploding exponentially. Though allopathic physicians and researchers maintain there is no known cause or treatment for the ultimately fatal illness, alternative practitioners understand the etiology has evolved from decades of living an unhealthy lifestyle. Dietary transgressions, exposure to cosmetic and household pollutants, lack of physical activity and long-term nutritional deficiencies all combine to promote Alzheimer’s disease development and progression.

A group of scientists have published the findings from their research in the Journal of Alzheimer’s Disease that has pinpointed how vitamin D3 and omega-3 fatty acids may enhance the immune system's ability to clear the brain of amyloid plaques. Researchers identified key genes and signaling networks regulated by vitamin D3 and the omega-3 fatty acid DHA (docosahexaenoic acid) that may help control inflammation and improve plaque clearance.

Vitamin D3 and DHA boost immune response to help prevent amyloid protein tangles

Prior studies have identified the loss of normal ability to break down amyloid proteins before they develop into tangles or plaques as a key process in the development of the memory-robbing disease. Lead study author, Dr. Milan Fiala from the David Geffen School of Medicine at UCLA commented “Our new study sheds further light on a possible role for nutritional substances such as vitamin D3 and omega-3 in boosting immunity to help fight Alzheimer's.”

To perform their study, scientists drew blood samples from both Alzheimer's patients and healthy controls and then isolated critical immune cells called macrophages from the blood. Macrophages are responsible for splicing the amyloid proteins before they can aggregate around the nerve synapse, effectively stifling electrical and chemical transmissions throughout the brain. Scientists then incubated the immune cells with amyloid-beta and added either an active form of vitamin D3 or the omega-3 fatty acid DHA to gauge effectiveness on inflammation and amyloid-beta absorption.

Supplement daily with Vitamin D3 and Omega-3 Fats to Slash Alzheimer’s Disease Risk

The researchers determined that vitamin D3 and DHA greatly improved the clearance of amyloid-beta by macrophages in patients with Alzheimer’s disease, and found subtleties in the effects the two substances had on the expression of inflammatory genes. The study team concluded “We may find that we need to carefully balance supplementation with vitamin D3 and omega-3 fatty acids, depending on each patient in order to help promote efficient clearing of amyloid-beta…. this is a first step in understanding what form and in which patients these nutrition substances might work best."

The study team observed that each nutrient (vitamin D and DHA) utilized different receptors and common signaling pathways to prevent amyloid protein aggregation leading to disease. Optimizing vitamin D blood saturation levels and supplementing with a molecularly distilled DHA omega-3 formulation can provide critical support in helping the brain to properly clear amyloid metabolic byproducts and help prevent Alzheimer’s dementia.

Carotenoids in Diet from Fruits and Vegetables May Help Prevent or Delay the Onset of ALS

Amyotrophic lateral sclerosis, better known as ALS, is a devastating degenerative illness that incapacitates its victims in a manner similar to those suffering from Alzheimer’s disease. At present, there is no known cure or effective treatment for the illness, believed to be the result of oxidative stress caused by decades of poor diet, stress, environmental toxins and poor physical conditioning. Researchers have now discovered that increased consumption of foods containing colorful carotenoids, particularly beta-carotene and lutein, may prevent or delay the onset of ALS.

Natural Sources of Fruits and Dark Leafy Vegetables Help Lower Risk of Developing ALS

ALS, or Lou Gehrig’s disease, is a progressive neurological disease that attacks nerve cells in the brain and spinal cord known to be responsible for the control of voluntary muscles. As the motor neurons degenerate, the muscles they control gradually weaken and waste away, leading to paralysis. A research team from the Harvard School of Public Health has published the results of their research in the Annals of Neurology that builds on prior studies showing that carotenoids, the natural compounds that give fruits and vegetables their bright orange, red, or yellow colors, provide critical antioxidant support to help fight this devastating disease.

Scientists evaluated five large studies comprising more than one million participants to develop a basis for evaluation. Researchers reviewed food intake for the group and further broke consumption down to determine carotenoids eaten in the form of fruits and vegetables. Lead study author Dr. Alberto Ascherio noted “Understanding the impact of food consumption on ALS development is important. Our study is one of the largest to date to examine the role of dietary antioxidants in preventing ALS.”

Add Five to Nine Daily Servings of Fruits and Vegetables to Your Natural Food Diet

A total of 1093 cases of ALS were identified across the cohort of subjects. The team found that those with the highest intake of carotenoids from any source had the lowest risk of developing ALS. They also determined that individuals who consumed more carotenoids in their diets were more likely to exercise, have an advanced degree, have higher vitamin C consumption, and take vitamin C and E supplements. Participants with the highest dietary consumption of beta-carotene and lutein, most commonly found in dark green vegetables had a reduced risk of developing ALS.

Interestingly, the researchers found that diets high in lycopene, beta-cryptoxanthin, and vitamin C did not reduce disease incidence, and long-term vitamin C supplement intake was also not associated with lower ALS risk. Dr. Ascherio concluded “Our findings suggest that consuming carotenoid-rich foods may help prevent or delay the onset of ALS.” This study acts to support a large volume of prior works that reinforce the critical importance of a natural food diet consisting largely of fruits and vegetables to thwart diseases ranging from cancer and diabetes to Alzheimer’s disease and ALS.

Active Compounds in Green Tea and Red Wine Halt Alzheimer’s Disease Progression

Alzheimer’s disease is characterized by an unnatural accumulation of amyloid plaque aggregates around nerve synapses that block the transmission of electrical and chemical transmitters that allow the brain to retain a high level of cognitive function and to store and retain memories. Millions of middle aged and older Americans suffer from some stage of Alzheimer’s disease, as the illness continues to escalate at an epidemic rate. It is projected that the prevalence will nearly quadruple in the next 50 years, by which time approximately 1 in 45 Americans will be afflicted with the disease.

Green Tea and Red Wine Extracts Impede Amyloid Formation to Prevent Alzheimer’s Development

The past decade has uncovered a small handful of natural, bioactive compounds that easily cross the blood-brain barrier where they have been found to alter the progression of Alzheimer’s disease. Researchers from the University of Leeds in the UK have determined that natural chemicals found in green tea and red wine may disrupt a key step of the Alzheimer's disease pathway. Publishing in the Journal of Biological Chemistry, scientists have identified the process which allows harmful clumps of protein to latch on to brain cells, causing them to die.

Scientists understand that amyloid proteins in the brain clump together to form toxic, sticky balls of varying shapes. These amyloid balls latch on to the surface of nerve cells in the brain by attaching to proteins on the cell surface called prions, ultimately causing nerve cells to malfunction and die. Study co-author Dr. Jo Rushworth commented "We wanted to investigate whether the precise shape of the amyloid balls is essential for them to attach to the prion receptors, like the way a baseball fits snugly into its glove.”

Supplement Daily with EGCG and Resveratrol to Slow Disease Progression

The team wanted to determine if it was possible to prevent the amyloid balls from binding to prions by manipulating their shape and stop the cells from dying. Scientists formed amyloid balls in a test tube and then added them to human and animal brain cells. Study authors concluded "When we added the extracts from red wine and green tea, which recent research has shown to re-shape amyloid proteins, the amyloid balls no longer harmed the nerve cells.”

Researchers determined that the bioactive compounds in green tea and red wine (EGCG and resveratrol) distorted the shape of the amyloid balls, preventing them from binding with prions and disrupting cellular function. Complimentary studies have also determined that curcumin, the active compound in the curry spice turmeric, crossed the delicate blood-brain barrier to halt the advancement of dementia. Health-minded individuals should consume green tea and red wine or take standardized supplements regularly to help prevent the initial development and progression of Alzheimer’s disease.

Deep Fried Foods Increase Aggressive Prostate Cancer Risk by One-Third

Prostate cancer will affect one in six men during the course of their lifetime, as nearly a quarter of a million new cases are diagnosed in the US each year. While many cases of the disease remain localized as a growing number of patients adopt a wait and see attitude toward the traditional slash, burn and poison treatment options, aggressive forms of prostate cancer are on the rise, threatening the lives of thousands of men annually.

Carcinogens Formed When Foods are Fried Dramatically Boost Prostate Cancer Risk

Despite ever-increasing awareness that diet and cooking methods plays a direct role in disease prevention and progression, consumption of overcooked and fried foods continues to increase at an alarming rate. A new research study conducted at the Fred Hutchinson Cancer Research Center in Seattle, WA has found that regular consumption of deep-fried foods is associated with an increased risk of prostate cancer. Publishing in The Prostate, scientists determined the effect appears to be slightly stronger with regard to more aggressive forms of the disease.

Past studies have shown that high heat cooking methods greatly increase the risk of developing not only prostate cancer, but digestive cancers as well. This is the first study to examine how eating fried foods increases the risk of prostate cancer. Study scientists analyzed data from two prior population-based case-control studies involving a total of 1,549 men diagnosed with prostate cancer and 1,492 age-matched healthy controls. Food questionnaires were used to determine consumption of foods including French fries, fried chicken, fried fish and doughnuts. Frequency of eating fried foods was also assessed as part of the overall evaluation.

Eliminate Fried Foods and Replace with Natural Vegetables and Fruits to Slash Cancer Risk

Researchers found that men who ate one or more of these foods at least weekly had an increased risk of prostate cancer that ranged from 30 to 37 percent. The lead study author, Dr. Janet Stanford commented “The link between prostate cancer and select deep-fried foods appeared to be limited to the highest level of consumption, defined in our study as more than once a week, which suggests that regular consumption of deep-fried foods confers particular risk for developing prostate cancer.”

The team determined that frying dramatically increases the formation of advanced glycation end products (AGE’s) on the surface of foods that triggers the formation of carcinogens such as acrylamides (found in carbohydrate-rich foods such as French fries), heterocyclic amines and polycyclic aromatic hydrocarbons (chemicals formed when meat is cooked at high temperatures), aldehydes and acrolein. Complete avoidance of foods cooked at high temperatures or fried will dramatically lower the risk of developing prostate cancer and other digestive cancers as well.

Vitamin D Important Factor in Aggressive Breast Cancer Prevention and Treatment

Breast cancer strikes more than one-quarter of a million women in the US each year, taking the lives of nearly 40,000 annually. While age, lifestyle, diet and physical activity all play a significant role in development of the disease, an estimated fifteen percent of women fall victim due to genetic susceptibility. Current treatment options include surgery, chemotherapy, radiation therapy, immunotherapy, and vaccine therapy, though extensive research clearly demonstrates that natural compounds, including vitamin D may play an effective role in the prevention and even treatment of breast cancer.

Researchers from Saint Louis University have discovered a molecular pathway that contributes to triple-negative breast cancer, an often deadly and treatment resistant form of cancer that tends to strike younger women. Publishing in The Journal of Cell Biology, scientists identified vitamin D and some protease inhibitors as possible new therapies. Additionally, the study team discovered a set of three biomarkers that can help to identify patients who could benefit from the treatment.

Vitamin D alters gene expression to prevent deadly mutations and lower breast cancer risk

Scientists know that women who are born with BRCA1 gene mutation are at increased risk for developing breast and ovarian cancers within their lifetime and the tumors that arise are frequently the triple-negative type. Genetic expression has been identified as the primary pathway that allows tumor cells to grow unchecked. The study team identified how vitamin D plays a role in turning off this pathway, providing a safe and effective strategy to fight these types of tumors.

The researchers sought to identify specific genes that either express of suppress the production of proteins that ultimately protect or promote the development of cancer cells. Each cell contains an extensive array of mechanisms designed to protect DNA integrity and prevent passing potentially damaging mutations to the next generation of daughter cells. BRCA1 is a well known tumor suppressor gene, as it helps repair DNA double-strand breaks, helping to prevent the initial phase of breast cancer lines. Loss of the BRCA1 gene repair ability greatly increases the risk of developing cancer.

Supplement Daily with Vitamin D to Ensure Maximum Cellular Saturation and Protection

The study team identified a critical DNA repair factor known as 53BP1 that becomes impaired with BRCA1 gene degradation, and determined that treatment of BRCA1-deficient tumor cells with vitamin D restores high levels of 53BP1, which results in increased genomic instability and reduced proliferation. The team determined that treatment with a combination of vitamin D and PARP inhibitors could represent a novel therapeutic strategy for breast cancers with poor prognosis.

Extensive research over the past decade has clearly shown that sub-optimal levels of vitamin D greatly increase the risk of many forms of cancer, as the prohormone unlocks the necessary blueprint to accurate cellular replication and elimination of mutations. This important study is among the first to identify vitamin D as a key to prevention and even treatment in the most resistant cases of triple-negative breast cancer lines. Most women will want to ensure they maintain optimal vitamin D blood levels between 50 and 70 ng/mL (higher for those fighting the disease) for protection against this deadly form of breast cancer.