Omega-3 fats from foods including
fish, chicken, nuts and seeds are preferentially sequestered after consumption
and used for critical functions to maintain optimal brain metabolism and
function. These long-chain fats are used to form the highly permeable cell wall
membrane of nerve cells, as electrical and chemical transmissions through this
barrier are limited when sufficient omega-3 fats are unavailable from blood
circulation.
Researchers from the Columbia
University Medical Center in New York have published the result of their work
demonstrating the close relationship between Omega-3 fats, blood saturation
levels of amyloid proteins and risk of developing Alzheimer’s disease in the
prestigious journal,
Neurology. The study confirms that
lower blood levels of a protein related to Alzheimer's disease (amyloid-beta
plaque) can protect against memory problems, mild cognitive decline and
progression to Alzheimer’s disease in many cases.
Increased Omega-3 Fats from Diet Reduces Beta-Amyloid Levels in the
Blood up to Thirty Percent
The lead study author, Dr.
Nikolaos Scarmeas noted “While it's not easy to measure the level of
beta-amyloid deposits in the brain in this type of study, it is relatively easy
to measure the levels of beta-amyloid in the blood, which to a certain degree,
relates to the level in the brain.” The brain normally generates amyloid
proteins as a metabolic byproduct that are broken down and cleared in the
youthful, healthy brain. The study suggests that Omega-3 fats from dietary
sources can aid this process, though the scientists did not specifically note
this conclusion.
Researchers looked at 1,219
people that were over the age of 65 and free of dementia. The participants
provided information regarding their diet for an average of 1.2 years before
their blood was tested for beta-amyloid. The scientists specifically monitored
ten nutrients including saturated fatty acids, omega-3 and omega-6
polyunsaturated fatty acids, mono-unsaturated fatty acid, vitamin E, vitamin C,
beta-carotene, vitamin B12, folate and vitamin D.
Consume Several Servings of Walnuts, Fish and Seeds Daily to Lowers Dementia
Risk
The study determined that higher
levels of omega-3 fats consumed by eating fish, chicken, nuts and seeds
directly correlated to lower blood beta-amyloid levels. Researchers found that
consuming one gram of omega-3 per day (equal to approximately half a fillet of
salmon per week) was associated with 20 to 30 percent lower blood beta-amyloid
levels. Researchers found that most people do not eat enough omega-3 enriched
foods to adequately raise blood levels of the essential fat.
Dr. Scarmeas concluded
“The more omega-3s one eats, the less the
beta amyloid levels are… we were able to relate something that we eat with
a very specific mechanism in the body that is very strongly related to
Alzheimer’s.” This study did not account for intake of the pre-formed
omega-3 fats supplied through fish oil supplements, known to dramatically boost
blood saturation of the long-chain fats. Nutrition experts suggest several
servings of fish, chicken, nuts and seeds each week (or supplementing with
1,200 to 2,400 mg EPA/DHA daily) to significantly lower the risk of developing
Alzheimer’s disease.